| 谈潘莉,曹毅,曹俊敏.白念珠菌性外阴阴道炎患者Th1/Th2细胞因子的研究[J].浙江中西医结合杂志,2012,22(3):175-177 |
| 白念珠菌性外阴阴道炎患者Th1/Th2细胞因子的研究 |
| Observation of Th1/Th2 Cytokines in Vaginal Fluid from Vulvovaginal Candidiasis Patients |
| 投稿时间：2011-10-20 |
| DOI： |
| 中文关键词: 念珠菌性外阴阴道炎 白念珠菌 Th1/Th2 |
| 英文关键词:vulvovaginal candidiasis canidia albicans Th1/Th2 |
| 基金项目: |
|
| 摘要点击次数: 1459 |
| 全文下载次数: 7 |
| 中文摘要: |
| 目的：观察白念珠菌性外阴阴道炎患者阴道分泌物Th1/Th2 细胞因子水平，探讨其在阴道
局部免疫功能中的作用。方法： 采用ELISA 检测阴道分泌物中细胞因子IFN-γ、IL-12、IL-4 及
IFN-γ/IL-4 表达情况。结果：念珠菌性外阴阴道炎组（VVC 组）阴道灌洗液细胞因子IL-12 明显高
于正常对照组及复发性念珠菌性外阴阴道炎组（RVVC 组）（P<0.05），RVVC 组与正常对照组间差
异无统计学意义（P>0.05）；IFN-γ、IL-4 在VVC 组与RVVC 组间差异无统计学意义（P>0.05），但均
高于正常对照组（P<0.05）；VVC 组与RVVC 组IFN-γ/IL-4 值均低于正常对照组（P<0.05）。结论：
VVC 患者阴道局部存在Th2 细胞极化，抑制Th1 细胞增殖及免疫功能的发挥，局部免疫功能紊乱
降低了对念珠菌感染的抵抗力。 |
| 英文摘要: |
| Objective: To observe the levels of Th1/Th2 cytokines in vaginal fluid from vulvovaginal vandidiasis(
VVC) patients and explore their roles in local immune response of vagina. Methods:The ELISA method was applied
to measure the expressions of IFN-γ, IL-12,and IL-4,and the ratio of IFN-γ to IL-4 ( IFN-γ/IL-4) in vaginal
fluid from 70 VVC patients and 35 healthy female subjects in the same hospital as controls. Results: In the
VVC group, the expression of IL-12 was markedly higher than that of the recurrent VVC group and the control
group(P<0.05), and no significant difference of IL-12 was seen between the later 2 groups(P>0.05). The expression
of IFN-γ and IL-4 in the VVC and recurrent VVC groups was not seen significant difference(P>0.05), but both
were higher than that of the control group(P<0.05). IFN-γ/IL-4 was decreased in the VVC and recurrent VVC
groups as compared with that of the control group(P<0.05).Conclusion: Th2 polarization existed in vagina local immune
response in VVC patients, which inhibited the proliferation of Th1 cytokines and the immune function. Thus
Canidia albicans may have an easy assess to infect the patient owing to the local disturbance of immune function. |
| 查看全文 查看/发表评论 下载PDF阅读器 |
| 关闭 |
