| 程 敏,叶小弟,郑高利,朱选文.川厚灵片改善糖耐量作用的实验研究[J].浙江中西医结合杂志,2012,22(6):435-437 |
| 川厚灵片改善糖耐量作用的实验研究 |
| Effect of Chuanhoulingpian on Glucose Tolerance in Diabetic Mice |
| 投稿时间：2011-12-30 |
| DOI： |
| 中文关键词: 小鼠 川厚灵片 血糖 糖耐量 |
| 英文关键词:mice Chuanhoulingpian blood glucose glucose tolerance |
| 基金项目: |
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| 摘要点击次数: 1796 |
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| 中文摘要: |
| 目的： 观察川厚灵片对糖尿病小鼠糖耐量的改善作用。方法： 采用正常小鼠和四氧嘧啶
糖尿病模型小鼠， 禁食一定时间后分别灌胃给予川厚灵片10、 5和2.5g/kg， 30min后作淀粉耐量试
验， 检测淀粉负荷后1~3h血糖水平， 并计算血糖曲线下面积AUC及AUC增加值。结果： 川厚灵片
能明显降低正常和糖尿病模型小鼠给淀粉后1~3h血糖水平， 使血糖AUC和ΔAUC显著降低， 并推
迟血糖达峰时间， 剂量关系明确。结论： 川厚灵片对正常和糖尿病小鼠淀粉负荷后的血糖水平有
明显的降低作用， 提示川厚灵片可改善糖耐量。 |
| 英文摘要: |
| Objective： To investigate the protective effect of Chuanhoulingpian on glucose tolerance in diabetic
mice. Methods: Diabetic mice was induced by alloxan. Diabetic mice were intragastrically given 10, 5, and 2.5
g/kg Chuanhoulingpian after fasting 6h for 7d. Mice in the control group and acarbose group were given tap wa?
ter and 100 mg/kg acarbose for 7 days, respectively. The level of blood glucose was measured at 0.5, 1, and 2
h after starch-administered. Glucose area under curve(AUC) and AUC added value were calculated. Results: The
level of blood glucose significantly decreased after Chuanhoulingpian intervention in a dose-dependent manner,
as well as the AUC and ΔAUC. Time to achieve the peak in the curve was delayed. Conclusion: Chuanhouling?
pian can decrease the level of blood glucose after starch administration, indicating that it can improve glucose
tolerance capability in diabetic mice. |
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