| 倪旭伟,张德忠,刘玉梅,叶永玲,徐媚媚.非糖尿病慢性肾病患者游离脂肪酸水平与
细胞因子及胰岛素抵抗的关系[J].浙江中西医结合杂志,2013,23(1):6-17 |
| 非糖尿病慢性肾病患者游离脂肪酸水平与
细胞因子及胰岛素抵抗的关系 |
| Relationship Between Serum Free Fatty Acid and Cytokines and Insulin Resistance in Non-DiabeticChronic Kidney Disease Patients |
| 投稿时间：2012-07-27 |
| DOI： |
| 中文关键词: 非糖尿病慢性肾病
游离脂肪酸
超敏C-反应蛋白
肿瘤坏死因子-α
胰岛素抵抗 |
| 英文关键词:non-diabetic chronic kidney disease
free fatty acid
high sensitive C-reactive protein
tumor ne?
crosis factor-α
insulin resistance |
| 基金项目: |
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| 摘要点击次数: 1356 |
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| 中文摘要: |
| 目的：观察非糖尿病慢性肾脏病（CKD）患者血清游离脂肪酸（FFA）水平及其与高敏C-反
应蛋白（hs-CRP）、肿瘤坏死因子（TNF-α）、胰岛素抵抗的关系。方法：测定118例非糖尿病CKD患
者（非透析治疗80例，血液透析38例）及50名健康人FFA、空腹胰岛素（FINS）、空腹血糖（FPS），同
时检测hs-CRP、TNF-α、血脂等指标，并计算胰岛素敏感指数（ISI）、稳态模型胰岛素抵抗指数
（Homa-IR），分析FFA与胰岛素抵抗的关系。结果：非糖尿病非透析和透析CKD患者血清FFA、
hs-CRP、TNF-α、Homa-IR、TG和LP（α）水平均较健康对照组显著升高（P<0.05或P<0.01），且透析
CKD组FFA、hs-CRP、TNF-α、FINS、Homa-IR、TG和 LP（α）水平较非透析CKD组明显升高（P<0.05
或P<0.01）；血FFA水平与hs-CRP、TNF-α、FINS、Homa-IR、TG和LP（α）呈正相关（P<0.01），与ISI
负相关（P<0.01）。结论：非糖尿病CKD患者FFA水平明显升高，且与hs-CRP、TNF-α及胰岛素抵抗
密切相关。 |
| 英文摘要: |
| Objective: To investigate the relationship between serum free fatty acid (FFA) and high sensitive C re?
active protein (hs-CRP)，tumor necrosis factor α (TNF-α)，and insulin resistance in patients with non-diabetic
chronic kidney disease (CKD). Methods: Serum FFA，fasting insulin （FINS），fasting plasma glucose (FPS),
hs-CRP, TNF-α, and the lipid profile were measured and compared between 118 patients with non-diabetic
CKD (non-dialytic 80 patients and dialytic 38 patients)and 50 normal controls. Insulin resistance was evaluated
by using insulin sensitivity index and homeostasis model assessment-insulin resistance index(Homa-IR). Results:
Serum FFA, hs-CRP, TNF-α，Homa-IR, triglyceride and lipoprotein(α) were significantly higher in non-diabetic
CKD patients compared to those in normal controls (P<0.05 or P<0.01). The increase of serum FFA,hs-CRP,
TNF-α，FINS, Homa-IR，triglyceride and lipoprotein(α) were higher in dialytic patients than those in non-dialyt?
ic patients (P<0.05 or P<0.01). In all patients,FFA was positively correlated with hs-CRP, TNF-α, FINS,
Homa-IR, triglyceride and lipoprotein(α) but was negatively related to insulin sensitivity index (P<0.01). Conclu?
sion: Serum FFA significantly increased in non-diabetic CKD patients and was closely correlated with insulin re?
sistance. |
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