| 余碧芸,吴宏成,沈世茉,潘登.支气管镜刷检标本液基细胞学检测在肺癌诊断中的应用[J].浙江中西医结合杂志,2013,23(2):92-94 |
| 支气管镜刷检标本液基细胞学检测在肺癌诊断中的应用 |
| Clinical Value of the SurePath Liquid-based Cytology Test in Cytological Screening of Bronchial Brush?ing for the Diagnosis of Lung Cancer |
| 投稿时间：2012-09-21 |
| DOI： |
| 中文关键词: 肺癌
支气管镜刷检标本
液基细胞学
传统涂片法 |
| 英文关键词:lung cancer
bronchial brushing
liquid-based cytology test conventional smear |
| 基金项目: |
|
| 摘要点击次数: 1358 |
| 全文下载次数: 0 |
| 中文摘要: |
| 目的：探讨对支气管镜毛刷标本进行液基细胞学检测（LCT）在肺癌诊断中的应用价值。
方法：收集159例肺癌患者和同期370例非肺癌患者的支气管镜刷检标本，同时进行LCT和直接涂
片法检测，比较两种方法的涂片质量及诊断的阳性率。结果：LCT检测的标本切片质量高，LCT诊
断肺癌的敏感度为43.4%，特异度为99.7%。直接涂片法诊断肺癌的敏感度为18.3%，特异度为
99.7%。LCT的敏感度高于直接涂片法（P<0.01），特异度与直接涂片法无差异。159例肺癌患者中
同时有LCT分类诊断和病理组织学诊断结果者69例，其中LCT分类诊断与病理组织学诊断相符53
例，总符合率为76.8%。结论：LCT检测技术能提高肺癌诊断率，支气管镜刷检标本的LCT检测可
推广应用于临床。 |
| 英文摘要: |
| Objective：To explore the clinical value of the SurePath liquid-based cytology test (LCT) in cytologi?
cal screening of bronchial brushing for the diagnosis of lung cancer. Methods: Bronchial brushing specimens
from 159 patients who were diagnosed as having lung cancer and 370 patients who were diagnosed as having be?
nign lung disease were studied. The diagnostic sensitivity and cytological findings of LCT were compared with
those of conventional smear (CS) method for diagnosing lung cancer. Results: LCT slides showed decreased areas
of cell monolayers, a clearer background and distinct, stereoscopic cytological features. LCT had a significantly
higher diagnostic sensitivity for lung cancer (43.4%) than the CS method (18.3%, P<0.05). The specificity was
the same between the 2 methods. Of the 69 cases which had both LCT and histopathological results, LCT and
pathology concordance rate was 76.8%. Conclusions: LCT in cytological screening of bronchial brushing has
more diagnostic value of lung cancer and can be easily performed. |
| 查看全文 查看/发表评论 下载PDF阅读器 |
| 关闭 |
