| 谢中华,章海华,汪铁军,郑元秀.非酒精性脂肪性肝病患者血清增食欲素A的变化及其与胰岛素抵抗的关系[J].浙江中西医结合杂志,2014,24(1): |
| 非酒精性脂肪性肝病患者血清增食欲素A的变化及其与胰岛素抵抗的关系 |
| The Changes of serum Orexin A in Nonalcoholic Fatty Liver Disease patients and the relationship between Orexin A with insulin resistance Xie Zhonghua , Zhang Hai-hua,Zheng Yuanxiu,Wang Tiejun , (Yuhang District Second People , s Hospital Of Hangzhou City,Hangzhou,311121) |
| 投稿时间：2013-02-26 修订日期：2013-10-16 |
| DOI： |
| 中文关键词: 非酒精性脂肪性肝病 增食欲素A 胰岛素抵抗 |
| 英文关键词:nonalcoholic fatty liver disease orexin A insulin resistance |
| 基金项目: |
|
| 摘要点击次数: 1925 |
| 全文下载次数: 0 |
| 中文摘要: |
| 【】 目的 观察非酒精性脂肪性肝病患者血清增食欲素A水平的变化及其与胰岛素抵抗的关系。方法 测定103例非酒精性脂肪性肝病患者及99例健康体检者的体重指数及腰臀比,采用酶联免疫吸附试验法检测其血清增食欲素A水平,同时检测其血脂水平、空腹胰岛素及空腹血糖,计算胰岛素抵抗指数,分析血清增食欲素A水平与胰岛素抵抗间的关系。结果 与健康对照组相比,非酒精性脂肪性肝病患者BMI、WHR、HOMA-IR及血清TC、TG、FFA水平均明显高于健康对照组(P＜0.05)；血清HDL-C及orexin A水平则显著低于健康对照组(P＜0.01,P＜0.05)；相关性分析表明：orexin A与BMI、WHR、TG、FFA、HOMA-IR均呈明显负相关(r分别为 -0.689、-0.741、-0.438、-0.377、 -0.611；P＜0.01)；与TC无明显相关性；orexin A与HDL-C呈明显正相关(r= 0.832,P＜0.01)。结论 非酒精性脂肪性肝病患者存在明显的脂代谢异常及胰岛素抵抗,Orexin-A可能通过调控胰岛素抵抗参与NAFLD的发生发展。 |
| 英文摘要: |
| 【】 Objective To investigate the changes of the level of serum orexin A in Nonalcoholic Fatty Liver Disease patients and the relationship between orexin A with insulin resistance. Methods Body mass index and waist-hip ratio of 103 patients with NAFLD and 99 individuals having general physical examination were measured .Fast blood glucose(FBG) and fast insulin(FINS) were measured for calculating the insulin resistance index. The level of serum orexin A were detected by ELISA.. The relationship of serum orexin A with Insulin resistance was statistically analyzed. Results Compared with healthy control group,the body mass index、waist-hip ratio、HOMA-IR and the levels of serum TC、TG、FFA was significantly higher(P＜0.05),but the levels of serum HDL-C and orexin A were decreased significantly(P＜0.01,P＜0.05). The level of serum orexin A was negatively correlated with BMI、WHR、TG、FFA、HOMA-IR(r= -0.689、-0.741、-0.438、-0.377、 -0.611；P＜0.01),but the level of serum orexin A was positively correlated with the HDL-C(r= 0.832,P＜0.01). Conclusions Lipid metabolism disorder and insulin resistance were observed in NAFLD patients; orexin A might play an important role in occurrence and development of NAFLD by modulating insulin resistance. |
| 查看全文 查看/发表评论 下载PDF阅读器 |
| 关闭 |
|
|
|
