| .赖建幸,朱博,陈建武.颅脑外伤合并骨盆骨折患者超敏C-反应蛋白测定的临床应用[J].浙江中西医结合杂志,2014,24(1): |
| 颅脑外伤合并骨盆骨折患者超敏C-反应蛋白测定的临床应用 |
| Clinical Application of The Hypersensitivity C-reaction Protein Determination on Craniocerebral Trauma Patients with Pelvic Fractures Chen Jianwu. Department of Respiratory Medicine,Pujiang County People |
| 投稿时间：2013-05-26 修订日期：2013-11-03 |
| DOI： |
| 中文关键词: 颅脑外伤 骨盆骨折 超敏C－反应蛋白 |
| 英文关键词:: Craniocerebral trauma pelvic fracture high sensitive C-reactive protein |
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| 中文摘要: |
| 【】目的：探讨颅脑外伤合并骨盆骨折患者血清超敏C－反应蛋白(hs-CRP)水平的动态变化及其对病情观察的意义。方法：将颅脑外伤合并骨盆骨折患者72例,全部经头颅CT、骨盆X片检查确诊。入院时即予格拉斯哥评分(GCS) ,将病人分为轻度( 13～15分)22例, 中度( 9～12 分)17例, 重度( 6～8分) 17例,特重度( 3～5分)16例。另设立骨盆骨折组,共23例,为同期骨科单纯骨盆骨折住院病人,对照组为同期门诊健康体检者70例。所有研究对象均排除心梗、肿瘤、风湿及急慢性感染等疾病。分别于伤后24小时、72小时检测血清hs-CRP水平。结果：轻度、中度、重度、特重度颅脑外伤合并骨盆骨折组在伤后24小时、72小时的hs-CRP水平,分别与对照组相比较,显著高于对照组(P<0.01)。轻度、中度、重度、特重度颅脑外伤合并骨盆骨折组在伤后24小时、72小时的hs-CRP水平,分别与骨盆骨折组相比较,血清hs-CRP显著高于骨盆骨折组(P<0.01)。而重度颅脑外伤合并骨盆骨折患者与轻度、中度颅脑外伤合并骨盆骨折患者相比,hs-CRP显著增高(P<0.01),且特重度组血清CRP显著高于重度颅脑外伤合并骨盆骨折组(P<0.01),骨盆骨折组血清hs-CRP显著高于健康对照组(P<0.01)。结论：颅脑外伤、骨盆骨折后hs-CRP明显升高。hs-CRP是反映颅脑损伤、骨盆骨折严重程度的理想指标,对判断伤情轻重、预测预后有重要意义。 |
| 英文摘要: |
| Objective: To study the dynamic changes of high-sensitivity C-reactive protein (hs-CRP) and its significance of observation on Craniocerebral trauma patients with pelvic fractures. Methods: 72 patients who had the craniocerebral trauma complicated with pelvic, all were diagnosed by head CT and pelvic X tablets. By given the Glasgow score (GCS) at the time of admission, the patients were divided into the mild group (13 ~ 15) in 22 cases, the moderate group (9 ~ 12) in 17 cases, the severe group (6 ~ 8) in 17 cases, the extremely severe group (3 ~ 5) in 16 cases. A total of 23 cases for the same period, simple pelvic fractures orthopaedics inpatients, as pelvic fracture group. And 70 cases which were over the same period of outpatient health examination as control group. All of the subjects were excluded from myocardial infarction, tumor, rheumatism and acute and chronic infections and other diseases. We detected serum hs-CRP levels in 24 hours and 72 hours after injury,.Results: Compared with control group, the hs-CRP levels of mild, moderate, severe, and extremely severe craniocerebral trauma complicated with pelvic fracture group after injury in 24 hours, 72 hours, significantly higher than that of control group (P < 0.01). Compared with pelvic fractures,,the hs-CRP levels of mild, moderate, severe, and extremely severe craniocerebral trauma complicated with pelvic fracture group after injury in 24 hours, 72 hours, significantly higher than that of pelvic fracture group (P < 0.01).Compared with mild, moderate traumatic brain injury with pelvic fracture patients,the hs-CRP of the severe craniocerebral trauma complicated with pelvic fracture patients,obviously increased (P < 0.01), and serum CRP of extremely severe group was significantly higher than that of severe craniocerebral trauma complicated with pelvic fracture group (P < 0.01), serum hs-CRP of pelvic fracture group was significantly higher than those of healthy controls (P < 0.01).Conclusion:Hs-CRP significantly increased after head trauma and pelvic fracture. Hs-CRP was an ideal indicator which could reflected the severity of traumatic brain injury?and pelvic fracture,.and it is important to judge the severity and prognosis prediction. |
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