| 夏迅.银杏叶提取物对轻度认知功能损害的影响[J].浙江中西医结合杂志,2013,23(11):876-882 |
| 银杏叶提取物对轻度认知功能损害的影响 |
| Effect of Ginkgo Biloba Extract on Mild Cognitive Impairment |
| 投稿时间：2013-06-21 |
| DOI： |
| 中文关键词: 轻度认知功能损害 阿尔茨海默病 银杏叶提取物 |
| 英文关键词:mild cognitive impairment Alzheimer's disease ginkgo biloba extract |
| 基金项目: |
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| 中文摘要: |
| 目的：观察银杏叶提取物对轻度认知功能损害（MCI）的影响。方法：MCI 患者245例，随机
分为治疗组（n=123）与对照组（n=122），两组均予基础治疗，治疗组加用银杏叶提取物40mg，1 天3
次，口服。两组治疗前、治疗6 个月及1 年行简易精神状态检查（MMSE）与画钟试验（CDT）。监测治
疗前后两组红细胞乙酰胆碱（RBC-Ach）及红细胞乙酰胆碱酯酶（RBC-AchE）活性。结果：治疗6 个
月及1 年，治疗组MMSE、CDT 积分均显著提高，且均高于同期对照组（P<0.01）；与治疗前比较，治
疗1 年治疗组RBC-Ach 含量显著升高（P<0.01），且高于对照组（P<0.01）；治疗组RBC-AchE 活性
水平显著下降（P<0.01），且低于对照组（P<0.01）。结论：银杏叶提取物能显著改善MCI 患者认知功
能，降低AD转化率，可能与其改善中枢胆碱能系统功能有关。 |
| 英文摘要: |
| Objective：To observe the therapeutic effect of Ginkgo biloba extract on mild cognitive impairment（MCI）.
Methods：A total of 245 MCI patients were randomly divided into treatment group（n=123）and control group（n=
122）. Both groups received basal therapy and the treatment group was given 40 mg Ginkgo biloba extract orally，3
times per day in addition. Mini-mental state examination（MMSE）and clock drawing task（CDT）were carried out to
examine the patient's mental state before and half a year and 1 year after treatment. Serum RBC-Ach and RBCAchE
were determined in both groups before and after treatment. Results：In half a year and 1 year treatment，the
patient in treatment group had higher scores in MMSE and CDT compared with control group at each time point
（all P<0.01）. Compared with that before treatment and that in control group，RBC-Ach was higher and RBC-AchE
was lower in patients in treatment group after 1-year treatment（all P<0.01）. Conclusion：Ginkgo biloba extract can
improve cognitive activity and reduce the conversion rate of MCI to Alzheimer's disease in patients with MCI，which
may be realized by regulating central cholinergic system. |
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