| 王建军,李开军.前列地尔治疗不稳定型心绞痛的临床疗效及对IL-6、TNF-ɑ、IL-10水平的影响[J].浙江中西医结合杂志,2014,24(7): |
| 前列地尔治疗不稳定型心绞痛的临床疗效及对IL-6、TNF-ɑ、IL-10水平的影响 |
| The clinical efficacy of alprostadil treatment of unstable angina and the effect on the level of IL-6, TNF-ɑ, IL-10 |
| 投稿时间：2013-11-06 修订日期：2014-02-21 |
| DOI： |
| 中文关键词: 前列地尔 不稳定型心绞痛 IL-6 IL-10 TNF-ɑ |
| 英文关键词:Alprostadil unstable angina IL-6 IL-10 TNF-ɑ |
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| 中文摘要: |
| 【】目的：探讨前列地尔治疗不稳定性心绞痛临床疗效及对IL-6、TNF-ɑ、IL-10水平的影响。方法：选取青田县人民医院心内科和丽水市中心医院心内科2012年1月-2013年1月收治的80例不稳定心绞痛患者,运用随机数字表法将其分为对照组(40例)和观察组(40例)。其中对照组患者给予常规对症支持治疗,观察组患者在对照组基础上加用前列地尔治疗,比较2周后两组临床效果、心电图改善情况、IL-6、TNF-ɑ、IL-10水平的改变。结果：治疗后,治疗组在心绞痛治疗显效率(42.5%)上明显高于对照组(20%),差异具有统计学意义(卡方=5.431,P<0.05)；治疗组在心电图显效率(47.5%)上明显高于对照组(25%),差异具有统计学意义(卡方=6.243,P<0.05)；两组患者治疗后IL-6、TNF-ɑ水平均较治疗前有明显降低,差异具有统计学意义(P<0.05,0.01),但治疗组患者治疗后IL-6、TNF-ɑ水平降低幅度较对照组更加明显,差异具有统计学意义(P<0.05)；两组患者治疗后IL-10水平较治疗前有明显升高,差异具有统计学意义(P<0.05,0.01),但治疗组患者治疗后IL-10水平升高幅度较对照组更加明显,差异具有统计学意义(P<0.05)。结论：前列地尔可有效抑制炎症反应,改善不稳定型心绞痛患者的临床症状,值得进一步推广和研究。 |
| 英文摘要: |
| Objective To investigate the clinical efficacy of alprostadil treatmentof unstable angina and the effect on the level of IL-6, TNF-ɑ, IL-10.Method 80 cases come from hospitaIizied sufferer with unstable angina in Cardiovascular Department of People's Hospital of Qingtian and Central Hospital of Lishui，from January,2012 to January,2013．Total 80 cases were divided into two groups：treatment group(40 eases)and treatment group (40 cases),the patients in the control group take general symptomatic and supportive treatment, the patients in the treatment group add Alprostadil based on treatment programs of the control group. Clinical effects, ECG improvement, the level of IL-6, TNF-ɑ, IL-10 were compared between treatment group and control group.Results The angina significant efficiency (42.5%) in the treatment group were significantly higher than those in the control group(20%), differences were statistical significance(x2=5.431，P<0.05); ECG significant efficiency (47.5%) in the treatment group were significantly higher than those in the control group(25%), differences were statistical significance(x2=5.431，P<0.05);The level of IL-6、TNF-ɑ in both groups were significantly lower than before treatment, differences were statistical significance(P<0.05),but, The level of IL-6、TNF-ɑ in the treatment group decreased significantly more than the control group, differences were statistical significance(P<0.05); The level of IL-10 in both groups were significantly higher than before treatment, differences were statistical significance(P<0.05,0.01),but, The level of IL-10 in the treatment group creased significantly more than the control group, differences were statistical significance(P<0.05).Conclusion Alprostadil can effectively suppress inflammation, improve clinical symptoms , worthy of further promotion and research.. |
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