| 王京霞,张琦,陈琳.复方大青颗粒急性毒性试验研究[J].浙江中西医结合杂志,2014,24(6): |
| 复方大青颗粒急性毒性试验研究 |
| Experimental study on acute toxicity of FuFangDaQing Granules |
| 投稿时间：2013-12-20 修订日期：2014-04-01 |
| DOI： |
| 中文关键词: 复方大青颗粒 ICR小鼠 体重 进食量 饮水量 最大给药量 |
| 英文关键词:FuFangDaQingGranules ICR mice weight food intake water intake the maximum dose |
| 基金项目: |
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| 中文摘要: |
| 目的:观察复方大青颗粒一次给药后的急性毒性反应情况,确定最大给药量。方法:用ICR小鼠48只,对复方大青颗粒进行急性毒性试验,首次给药一次,连续观察一周,考察对小鼠体重、进食量及饮水量的影响。结果：给药后连续14天,复方大青颗粒对小鼠体重增长无影响,对小鼠进食量和饮水量无明显影响。结论：复方大青颗粒给药后连续观察14天,各项指标均未见异常,日最大给药量为56g/kg,相当于临床剂量的311倍。 |
| 英文摘要: |
| Objective: By observing the acute toxicity reaction of FuFangDaQing granules to determine the maximum dosage.Method: With 48 ICR mice, by FuFangDaQing granules administration continuous 14d to observe the influence on mice body weight, food intake and water intake.Results: after administrati for 14 consecutive days, FuFangDaQing granuleson mice body weight growth has no effect, no obvious effects on mouse eating and water intake.Conclusion:The FuFangDaQing granules after administration for 14 days, each index was normal, the maximum dosage was 56g/kg, equivalent to 311 times the clinical dose. |
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