| 张庆元,刘丽,王耀光.张庆元 刘丽 王耀光[J].浙江中西医结合杂志,2015,25(1): |
| 张庆元 刘丽 王耀光 |
| Early assessment and intervention in elderly patients with first stroke depression. ZHANG Qing-yuan, LIU li, WANG Yao-guang. The people’s hospital of Wen Zhou City,Wen Zhou 325000,China. |
| 投稿时间：2014-05-28 修订日期：2014-08-26 |
| DOI： |
| 中文关键词: 老年 卒中后抑郁 早期干预 汉密尔顿抑郁量表 |
| 英文关键词:elderly post-stroke depression early intervention Hamilton Depression Scale |
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| 中文摘要: |
| 【】 目的：前瞻性观察老年首发脑卒中后一周抑郁状态的干预对神经功能恢复的影响。方法：选取发病一周的序贯住院老年首发脑卒中患者100例,分为帕罗西汀干预组和对照组(各50例)。于发病后第8、38天分别行汉密尔顿抑郁量表(Hamilton Depression Scale,HAMD)和美国国立卫生研究院脑卒中量表(National Institutes of Health stroke scale,NIHSS)评定；干预组患者于发病第8天给予帕罗西汀20mg 每日晨口服,对照组不予任何心理干预。 结果：干预组、对照组第8天抑郁状态的发生率分别为64.00％、62.00％,组间比较差异无统计学意义(P＞0.05),干预组、对照组于发病第38天抑郁状态的发生率分别为20.00％、38.00％,差异有统计学意义(P<0.05)；干预组在发病第8、38天的抑郁状态评分和神经功能缺损程度评定分别是HAMD：11.52±5.88、6.22±5.19,NIHSS：11.02±3.67、6.24±2.33,治疗前、后两次抑郁状态评分和神经功能缺损程度评定差异均有统计学意义(P<0.05)；对照组在发病第8、38天的抑郁状态评分和神经功能缺损程度评定分别是HAMD：10.80±5.56、8.04±4.21,NIHSS：10.70±2.95、7.88±1.86,治疗前、后两次抑郁状态评分和神经功能缺损程度评定差异均有统计学意义(P<0.05)；发病第38天时干预组较对照组的抑郁状态评分和神经功能缺损程度评定比较差异均有统计学意义(P<0.05)。结论：老年首发脑卒中后一周抑郁状态发生率高,早期药物干预有利于神经功能恢复。 |
| 英文摘要: |
| Objective To prospectively observe intervention depression state in elderly patients with first stroke on a week onset effect on neural function recovery. Methods Sequential 100 hospitalized elderly patients with first stroke on a week onset were divided into fluoxetine treatment group (50 cases) and the control group (50 cases).. After the onset of 8,38 days, respectively assessed with HAMD (Hamilton Depression Scale, HAMD) and NIHSS (National Institutes of Health stroke scale，NIHSS); intervention group were given at the onset of the first eight days of oral paroxetine 20mg daily morning, the control group did not receive any psychological intervention.Results The incidence of depression state of intervention group and the control group on the first 8 days of stroke onset is 64.00％、62.00％,respectively , between the two groups showed no significant difference (P>0.05);the intervention group and the control group in the first 38 days of onset the incidence of depression was 20.00％、38.00％,respectively, the difference was statistically significant (P<0.05); intervention group assessed the onset of 8,38 -day depression scores and neurological deficits were HAMD：11.52±5.88、6.22±5.19，NIHSS：11.02±3.67、6.24±2.33, two depression scores and neurologic impairment assessment between no treatment and treated were statistically significant differences (P <0.05); the control group assessed the onset of 8,38 -day depression scores and neurological deficits were HAMD：10.80±5.56、8.04±4.21，NIHSS：10.70±2.95、7.88±1.86, two depression scores and neurologic impairment assessment between no treatment and treated were statistically significant differences (P<0.05); The first 38 days of the onset of assessed intervention group compared with depression scores and neurological deficits in the control group were statistically significant differences (P<0.05). Conclusion The incidence of depression state in elderly patients with first stroke on a week onset was high, the sooner the better efficacy of drug intervention , in favor of neurological recovery. |
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