| 管彩虹,楼雅芳,赵凯,吴清.趋化因子CCL22对肺癌细胞迁移和侵袭的影响[J].浙江中西医结合杂志,2015,25(1): |
| 趋化因子CCL22对肺癌细胞迁移和侵袭的影响 |
| Effects of Chemokine CCL22 in lung cancer cell migration and invasion |
| 投稿时间：2014-06-10 修订日期：2014-10-29 |
| DOI： |
| 中文关键词: 趋化因子CCL22 肺癌细胞 肿瘤侵袭 肿瘤转移 |
| 英文关键词:Chemokine CCL22 Lung cancer cell Cancer invasion Cancer migration |
| 基金项目:杭州市医药卫生科技计划资助项目（2011A046）；浙江省医药卫生科技计划资助项目（2011KYA138） |
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| 中文摘要: |
| 目的:研究趋化因子CCL22对肺癌SBC-5细胞迁移和侵袭的影响。方法: 流式细胞术检测肺癌SBC-5细胞表面受体CCR4的表达水平；100ng/ml 的CCL22诱导肺癌SBC-5细胞后,观察细胞迁移及侵袭能力的变化及加入蛋白激酶抑制剂(U0126)后细胞迁移及侵袭能力的变化。结果:肺癌SBC-5细胞表面有CCR4受体的表达,CCL22诱导肺癌SBC-5细胞后,细胞迁移及侵袭能力明显增加,蛋白激酶抑制剂(U0126)可以抑制CCL22诱导肺癌细胞迁移及侵袭。结论:趋化因子CCL22在体外可以诱导肺癌SBC-5细胞迁移和侵袭。 |
| 英文摘要: |
| Objective: To investigate the effect of chemokine CCL22 in lung cancer cell line SBC-5 migration and invasion. Methods: Cell-surface expression of CC chemokine receptor4(CCR4) was detected by fluorescence-activated sorting . Capability of lung cancer cell migration and invasion was viewed, after lung cancer cells line SBC-5 were induced with 100ng/ml CCL22 and were added by protien kinase inhibitor(U0126).Rusults: CCR4 was expressed in lung cancer cell-surface, and capability of lung cancer cell migration and invasion increased significantly. Protein kinase inhibitor(U0126)may inhibit lung cancer cell migration and invasion induced CCL22.Conclusion: Chemokine CCL22 may induce migration and invasion of lung cancer cell line SBC-5 in vitro. |
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