| 杨小敏 潘丹 陈艳梅 郑翔 冯国飞 温州市人民医院 温州,徐晓武,潘丹,陈艳梅,郑翔,冯国飞.HIF-1α和Sema 4D在乳腺癌组织中的表达及其相关性研究[J].浙江中西医结合杂志,2014,24(12): |
| HIF-1α和Sema 4D在乳腺癌组织中的表达及其相关性研究 |
| Studies on the expressions and correlation of HIF-1αand Sema 4D protein in human breast carcinoma YANG Xiao-min, XU Xiao-wu , PAN dan, et al. The People’s Hospital of Wenzhou, Wenzhou 325000 |
| 投稿时间：2014-07-28 修订日期：2014-10-20 |
| DOI： |
| 中文关键词: 乳腺肿瘤 缺氧诱导因子-1α Sema 4D 淋巴管密度 |
| 英文关键词:Breast neoplasms Hypoxia inducible factor-1 alpha Semaphorin 4D lymphatic microvessel density |
| 基金项目:Sema4D蛋白在乳腺癌中的表达及其与淋巴道转移关系的研究 |
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| 中文摘要: |
| 目的：检测HIF-1α和Sema 4D在乳腺癌组织中的表达,并探讨其与乳腺癌临床病理指标的相关性。方法：采用免疫组织化学SP法检测110例乳腺癌组织中HIF-1α和Sema 4D的表达,同时检测微淋巴管密度(LVD),结合临床病理特征进行相关性分析。结果：乳腺癌组织中HIF-1α和Sema 4D蛋白的阳性表达率分别为72. 72% (80/110)、77.27%(85/110)；HIF-1α与Sema 4D表达呈正相关性(r=0.691, P<0.01)。HIF-1α、Sema 4D表达阳性组与阴性组的LVD差异显著(P<0.01)。HIF-1α和Sema4D的表达阳性率与TNM分期和淋巴结转移呈正相关(P＜001),与性别、年龄、组织学分级、肿块大小无相关性,差异无统计学意义(P＞005)。结论：HIF-1α、Sema 4D在乳腺癌组织中呈高表达,其表达与肿瘤淋巴管密度及淋巴结转移有关,对判断乳腺癌预后有一定的指导意义。 |
| 英文摘要: |
| Objective: To explore the expressions of HIF-1αand Sema 4D in breast carcinoma and their correlation with various clinical and pathological datum. Methods: The expressions of HIF-1αand Sema 4D in breast carcinoma were detceted by immunohistochemical SP method, The lymphatic vessels density (LVD) in tumor were counted through the special marker D2-40. analyze the correlation of HIF-1αand Sema 4D in breast carcinoma with various clinical and pathological datum. Results: The positive rates of HIF-1αand Sema 4D expressions were 72.72% (80/110) and 77.27% (85/110), respectively. The LVD were higher in HIF-1αor Sema 4D positive group than negative (P<0.01). Sema4D expression were positively correlated with HIF-1αexpression (r=0.691, P<0.01). The LVD’s difference is significant between HIF-1αand Sema4D positive group and nagtive group (P<0.01). The positive rates HIF-1αand Sema 4D have positive correlation with TNM stage and lymphatic metastasis,have insignificantce with Sex, Age, histological differentiation and tumor sizes. Conclusions: The expression of HIF-1αand Sema4D were high in breast carcinoma, which were closely related with tumor LVD and lymph node metastasis. It has significance prognosis for the patients with breast cancer. |
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