| 钱绿丽,丁彩飞.安宫方治疗封闭抗体低下型复发性自然流产临床观察[J].浙江中西医结合杂志,2015,25(3): |
| 安宫方治疗封闭抗体低下型复发性自然流产临床观察 |
| Therapeutic Efftct of Angong Decoction on Recurrent Spontaneous Abortion caused by Lacking of Blocking Antibodies |
| 投稿时间：2014-09-18 修订日期：2014-10-17 |
| DOI： |
| 中文关键词: 安宫方治疗 配偶淋巴细胞主动免疫治疗 复发性自然流产 封闭抗体 |
| 英文关键词:Angong Decoction, active immunity with paternal lymphocyte treatment, recurrent spontaneous abortion (RSA), blocking antibodies (BA) |
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| 中文摘要: |
| 【】目的：比较安宫方治疗和配偶淋巴细胞主动免疫治疗(简称“免疫治疗”)对封闭抗体低下复发性自然流产(Recurrent spontaneous abortion, RSA)的临床疗效。方法：封闭抗体阴性的 RSA患者44例, 随机数字表法等分成两组:中医治疗组,给予安宫方治疗3个月；西医对照组,予免疫治疗3个月,比较两组患者临床疗效情况。结果：封闭抗体转阳数比较：治疗前两组患者含抗CD3-BE、抗CD4-BE、抗CD8-BE的总阳数无显著性差异(Z=-0.821,P =0.412),具有可比性。治疗后两组含抗CD3-BE、抗CD4-BE、抗CD8-BE总阳数较治疗前均明显升高,有显著性差异P＜0.05。临床症状比较：治疗前两组患者临床症状总积分间差异无统计学意义(t=0.656,P =0.515)。治疗后安宫方组临床症状总积分较前减少,差异有统计学意义(t=5.257,P <0.001),免疫治疗组差异无统计学意义(t=0.655, P >0.001)。总临床疗效比较：安宫方组治愈4例、显效11例、有效4例、无效3例 (Z=﹣2.211,P=0.027),有效率86.37%,免疫治疗组治愈1例、显效6例、有效10例、无效5例(Z=﹣2.211,P=0.027),有效率77.27%。安宫方治疗组有效率高于免疫治疗组。结论：安宫方治疗能显著提高封闭抗体低下型RSA的封闭抗体转阳数及临床症状；免疫组能提高封闭抗体低下型RSA的封闭抗体转阳数,但不能改善临床症状。安宫方治疗组的治疗效果优于免疫治疗组。 |
| 英文摘要: |
| Objective To compare the clinical effects between Angong decoction and paternal lymphocyte treatment on recurrent spontaneous abortion (RSA) caused by lacking of blocking antibodies. Methods A total of 44 RSA patients with lacking blocking antibodies (BA) were divided randomly into two groups. Each group has 22 subjects. Experimental group was treated with Angong Decoction for 3 months while the control group with paternal lymphocyte treatment in order to compare the increasement of BA indexes and the improvement of clinical symptoms. Results There was no statistically significant difference in the number of positive- blocking antibodies(CD3-BE, CD4-BE,CD8-BE) among the two groups before treatment（Z=-0.821,P =0.412）. However, Both Angong decoction and paternal lymphocyte treatment can promote elevation of BA indexes（ P＜0.05）.There was no such significant difference in the total scores of clinical symptoms among the two groups before treatment（t=0.656,P =0.515）.The total scores of clinical symptoms in Angong decoction group were significantly lower after treatment（t=5.257,P <0.001）,but no such significant difference was noted in the paternal lymphocyte treatment group（t=0.655,P >0.001）.Based on the results of clinical effect, Angong decoction was cured 4 patients, remarkably effective in 11 patients, effective in 4 patients, and ineffective in 3 patients(Z=﹣2.211,P=0.027), the effective rate was 86.37%; The paternal lymphocyte treatment was cured 1 patients, remarkably effective in 6 patients, effective in 10 patients, and ineffective in 5 patients(Z=﹣2.211,P=0.027), the effective rate was 77.27%.Conclusion Angong decoction can promote both the number of positive- blocking antibodies and the total scores of clinical symptoms，while paternal lymphocyte treatment can only increase the number of positive- blocking antibodies. The therapeutic effect of the experimental group with Angong decoction was significantly better than that of control group with paternal lymphocyte treatment. |
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