| 黄林军,钱雪琴,沈中良.何首乌及其制剂致肝损伤19例临床分析[J].浙江中西医结合杂志,2015,25(4): |
| 何首乌及其制剂致肝损伤19例临床分析 |
| A Clinical Analysis on 19 Cases of Liver Injury Caused by Polygonum Multiflorum and Its Preparations |
| 投稿时间：2014-09-27 修订日期：2014-09-27 |
| DOI： |
| 中文关键词: 何首乌 肝损伤 临床分析 |
| 英文关键词:polygonum multiflorum liver injury clinical analysis |
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| 中文摘要: |
| 【】 目的 分析何首乌致药物性肝损伤的临床特征。方法 回顾性分析何首乌及其制剂致药物性肝损伤19例的临床资料。结果 从用药到发病时间在10-96天,大多在30天左右；临床表现主要为乏力、纳差、黄疸；肝损伤类型：肝细胞损伤型12例(63.1%),胆汁淤积型1例(5.4%),混合型6例(31.5%)；及时停用何首乌及其制剂,积极治疗均治愈出院。结论 何首乌及其制剂可致肝损伤,临床上需要合理规范使用,长期应用需要监测肝功能,早发现、早治疗大多预后良好。 |
| 英文摘要: |
| 【】Objective To analyze the clinical features of the drug-induced liver injury caused by polygonum multiflorum. Methods A retrospective analysis of the clinical data of 19 cases of liver injury caused by polygonum multiflorum and its preparations. Results The time from medication to paroxysm is 10-96 days, mostly 30 days or so; The clinical manifestations are mainly fatigue, anorexia, and jaundice; The types of liver injury: 12 cases (63.1%) of hepatocellular injury, 1 case (5.4%) of cholestasis, and 6 cases (31.5%) of mixed type; Timely stop taking polygonum multiflorum and its preparations and accept active treatment, which can enable patients to be cured and leave hospital. Conclusion Polygonum multiflorum and its preparations can cause liver injury. The use of polygonum multiflorum and its preparations should conform to the specification reasonably in clinical cases. For the long-term application, the liver function needs to be monitored. Early detection and early treatment can achieve favorable prognosis. |
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