| 李辰或,胡雪珍,郑贵成,陈琴男.白芍总苷对冠心病伴牙周炎患者治疗机制的研究[J].浙江中西医结合杂志,2015,25(8): |
| 白芍总苷对冠心病伴牙周炎患者治疗机制的研究 |
| Study of total glucosides of paeony in treatment of periodontitis patients with mechanism of coronary heart disease |
| 投稿时间：2014-10-24 修订日期：2015-05-25 |
| DOI： |
| 中文关键词: 白芍总苷,冠心病,牙周炎,机制 |
| 英文关键词:Total Glucosides of paeony, coronary heart disease, periodontitis, mechanism |
| 基金项目:温州市科技计划项目(Y20120270)通讯作者：李辰或，Tel：13906631227；E—mail：wzlch72@126.com |
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| 中文摘要: |
| [摘要]目的：通过对冠心病伴牙周炎患者采用白芍总苷进行治疗，探讨其对牙周炎的治疗机制及牙周炎影响冠心病的可能途经，以进一步拓展白芍总苷的临床应用。方法：选择门诊就诊人群中患有稳定型冠心病伴发慢性牙周炎患者，在检查后1个月内进行全口洁治，治疗组加服白芍总苷胶囊，治疗后3个月复诊，对所有受试者的牙周状况进行再评价并进行T淋巴细胞亚群和冠心病血清学指标的检测。结果：治疗前后患者牙周指数变化均有显著性差异（P＜0.001），T淋巴细胞亚群测定冠心病(coronary heart disease，CHD)组CD3 、CD4 、CD8 治疗前后比较具有显著性差异（P＜0.001），pearson相关分析显示对照组和CHO组治疗前后的牙周探诊深度(probingdepth，PD)与平均附着丧失 (attachment loss，AL)存在相关性。结论：白芍总苷可以在多个环节影响自身免疫疾病的细胞免疫、体液免疫以及炎症过程，可以减轻自身免疫性炎症，通过控制牙周组织免疫性炎症及减轻心肌缺血再灌注损伤的途径，改善牙周健康状况同时保护心肌组织，有助于降低冠心病诱发风险，在冠心病伴牙周炎患者及牙周炎合并其他系统疾病患者治疗中是一种有独特应用价值的新药。 |
| 英文摘要: |
| [Abstract] Objective: Patients with coronary heart disease periodontitis treatment using TGP explore the possible mechanism and treatment of periodontitis through its effects on coronary heart disease periodontitis, to further expand TGP's clinical application. Methods: outpatient populations with chronic periodontitis patients with stable coronary artery disease, full-mouth scaling after inspection within a month, the treatment group took TGP capsules, three months after treatment, referral, periodontal status of all subjects were re-evaluated and examined T lymphocyte subsets and serum markers of coronary heart disease. Results: After treatment, patients with periodontal index changes were significant differences (P <0.001), T lymphocyte subsets determination of coronary heart disease (coronary heart disease, CHD) group, CD3 , CD4 , CD8 before and after treatment with a significant difference (P <0.001), pearson correlation analysis showed that the control group before and after periodontal treatment group and CHO probing depth (probingdepth, PD) and mean attachment loss (attachment loss, AL) correlation. Conclusion: TGP can in many processes affect cell immunity, humoral immunity and autoimmune diseases of the inflammatory process, can reduce the autoimmune inflammation, through the control of periodontal tissue inflammation and alleviate myocardial ischemia reperfusion injury way, improve the periodontal health status and protect myocardial tissue, helps to reduce the risk of coronary heart disease induced by in patients with chronic periodontitis and coronary heart disease, periodontitis and other system diseases in the treatment of patients is a new drug has a unique application value. |
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