| 赵娜,胡万华,黄建平,叶人,孙书臣,何金彩.中医辨证治疗亚健康失眠的临床疗效观察[J].浙江中西医结合杂志,2015,25(6): |
| 中医辨证治疗亚健康失眠的临床疗效观察 |
| The observation of clinical efficacy of TCM treatment on sub-healthy insomnia based on the pattern differentiation |
| 投稿时间：2014-10-26 修订日期：2015-01-02 |
| DOI： |
| 中文关键词: 阴虚火旺 心脾两虚 亚健康失眠 疗效观察 |
| 英文关键词:yin deficiency with effulgent fire deficiency of both the heart and spleen Sub-healthy Insomnia the Observation on the Clinical Curative Effect |
| 基金项目:“十一五”国家科技支撑计划“亚健康失眠的中医药干预”项目（No．2006BAI13B06） |
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| 中文摘要: |
| 目的 观察中医辨证治疗阴虚火旺和心脾两虚型亚健康失眠的临床疗效。方法 采用多中心、单盲、随机对照研究方法,将符合纳入标准的亚健康失眠受试者随机分为中医辨证汤药治疗组(A组96例)和中成药乌灵胶囊治疗对照组(B组94例)。1周为1个疗程,共4个疗程,每周复诊1次。比较各组治疗前后及2组间的匹兹堡睡眠质量量表(PSQI)评分、临床医生总体印象(CGI)评分及WHO生活质量测定量表简明版(WHOQOL-BREF)评分以评估其疗效。结果 2组治疗前后PSQI、CGI及WHOQOL-BREF评分均有改善(P＜0.01)；2组间治疗各时点及停药2周后的CGI分值有统计学差异(P＜0.01)；2组间治疗前后的WHOQOL-BREF评分差值,A组均高于B组,其中生存质量总分和心理领域分值的差异有统计学意义(P<0.05)。结论 基于辨证的中药汤剂干预对阴虚火旺和心脾两虚型的亚健康失眠者的失眠及生活质量均有明显改善,安全性和依从性良好,且在改善患者的总体生存质量及心理状况方面明显优于中成药乌灵胶囊组。 |
| 英文摘要: |
| Objective： To observe the clinical efficacy of TCM treatment on sub-healthy insomnia with the pattern of yin deficiency with effulgent fire and the pattern of deficiency of both the heart and spleen. Method： To adopt the research methods of the multi-center， single-blind and randomized controlled， the subjects of sub-healthy insomnia who met the inclusion criteria were randomly divided into the treatment group （A Group） of TCM Decoction and the treatment controlled group （B Group） of Wuling capsule. One course of treatment is one week， the total courses of treatment are four， and one subsequent visit is in every week. To compare with Pittsburgh sleep quality index （ PSQ I） score， clinical global impression-improvement （ CGI）score， quality of life made by WHO （WHOQOL-BREF） score between each group before and after treatment and two groups to evaluate the effectiveness. The analytical data is included Group A with 96 cases and Group B with 94 cases. Result： The PSQI Evaluation、CGI Evaluation and WHOQOL-BREF Evaluation in two groups were improved before and after treatment （ P ＜0. 01）； The statistical difference is in CGI Evaluation which is between two groups at each time point after treatment and CGI Evaluation which is drug withdrawal after two weeks （P < 0.01）； To compare with deviations between WHOQOL-BREF Evaluation in two groups before and after treatment， the total score of quality of life in Group A and the scores of Group A in the fields of physiology， psychology， environment， social relations are all higher than the scores of Group B， in which the difference between the total score of quality of life and the score in the psychological field was statistical significance （P<0.05）. Conclusion： The differentiation of TCM interference for insomnia and the quality of life on sub-healthy insomnia with yin deficiency with effulgent fire pattern and deficiency of both the heart and spleen pattern is improved significantly ， it has better safety and compliance. Moreover， the differentiation of TCM interference which is in improving the patients on the overall quality of life and the aspect of psychologic status is superior to the controlled group. |
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