| 武剑,周虹,李晓.横纹肌样型脑膜瘤临床病理学分析--附2例报告[J].浙江中西医结合杂志,2015,25(8): |
| 横纹肌样型脑膜瘤临床病理学分析--附2例报告 |
| Clinicopathologic analysis of rhabdoid meningioma. |
| 投稿时间：2014-12-05 修订日期：2015-03-06 |
| DOI： |
| 中文关键词: 脑膜瘤 横纹肌样型脑膜瘤 临床病理 免疫组化 鉴别诊断 |
| 英文关键词:Meningioma Rhabdoid meningioma Clinicopathology Immunohistochemisty Differential diagnosis |
| 基金项目:杭州市医药卫生计划(2012B005) |
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| 中文摘要: |
| 【】 目的：探讨横纹肌样型脑膜瘤(rhabdoid meningioma,RM)的临床病理学特征、免疫表型、诊断及鉴别诊断。方法：收集本院横纹肌样型脑膜瘤2例,观察和分析临床病理学特征及免疫表型特点,复习相关文献并讨论。结果：肿瘤主要由横纹肌样细胞组成,其中例1可见典型的脑膜上皮细胞型脑膜瘤形态,与横纹肌样细胞有过渡；例2肿瘤完全由横纹肌样细胞构成。肿瘤细胞中等偏大,圆形或卵圆形,胞浆丰富,嗜酸性；细胞核偏位,核仁明显,核内假包涵体易见；局灶见出血和坏死。免疫组化显示肿瘤细胞EMA、Vimentin染色阳性,S-100 、Desmin、SMA、HMB45、GFAP、CD68、CDl38和LCA等染色均阴性。结论：RM是一种少见的脑膜瘤亚型,具有侵袭性和临床进展迅速的特点,极易复发和转移,预后较差。肿瘤细胞具有典型的横纹肌样细胞形态,需要依靠免疫组化与非典型畸胎样瘤/横纹肌样瘤、肥胖细胞型星形细胞瘤、横纹肌肉瘤、恶性黑色素细胞瘤、浆细胞瘤等肿瘤相鉴别。 |
| 英文摘要: |
| Objective: To investigate the clinicopathological features,immunophnotype and differential diagnosis of Rhabdoid meningioma (RM)． Methods： Two cases were studied by analyses of histopathologic features and immunohistochemistry,and also summarized and reviewed. Results ：RM was mainly composed of rhabdoid cells that were moderately large and round or oval with abundant eosinophilic cytoplasm,eccentric nuclei,prominent nucleoli and paranuclear inclusions．It Was positive |
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