| 王捷.CTOP-P与CHOP方案治疗晚期非霍奇金淋巴瘤的临床对照观察王捷 杨军礼 赵晶磊 赵霖 浙江金华广福医院肿瘤内科 321000[J].浙江中西医结合杂志,2015,25(9): |
| CTOP-P与CHOP方案治疗晚期非霍奇金淋巴瘤的临床对照观察王捷 杨军礼 赵晶磊 赵霖 浙江金华广福医院肿瘤内科 321000 |
| clinicalSeffecacySonStreatmentSofSSlateSnon-hodgkin"sSlymphomaSwithSCTOP-PScompareSwithSCHOPSregimen.WangJie,Yang JunLi,Zhao Jinglei,et al JinHua guangfu hospital,Zhejiang321000,China |
| 投稿时间：2015-01-18 修订日期：2015-03-08 |
| DOI： |
| 中文关键词: CTOP-P CTOP 晚期非霍奇金淋巴瘤 |
| 英文关键词:CTOP-P CTOP advanced non-hodgkinSlymphoma |
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| 中文摘要: |
| 目的 对比CTOP-P方案和CHOP方案治疗晚期非霍奇金淋巴瘤的临床疗效,毒性反应及生活质量评分。方法 将我院从2009年至2013年收治的72例晚期非霍奇金淋巴瘤患者按照随机数字表分为观察组和对照组,观察组37例采用CTOP-P方案,对照组35采用CHOP方案,3个疗程结束后,观察两组临床有效率,毒性反应及EORTC QLQ—C30评分。结果 对比两组有效率,观察组64.8%,对照组35.0%,有统计学差异,P<0.05,观察组临床有效率较高；对比两组毒性反应,在胃肠道反应,脱发,心脏毒性和骨髓抑制方面,观察组毒性反应较少,两组数据有统计学差异,P<0.05；对比两者化疗后生活质量评分,在功能项目中的躯体功能,角色功能,社会功能及认知功能上,在症状项目中的食欲减退,恶心呕吐,疼痛,呼吸困难,睡眠不佳及其他不适症状上,观察组评分低于对照组,两组数据有统计学差异,P<0.05,观察组化疗后的EORTC QLQ—C30生活质量评分优于对照组。结论 CTOP-P方案疗效确切,毒性反应相对少,化疗后患者耐受度好,可作为晚期非霍奇金淋巴瘤化疗方案推广应用。 |
| 英文摘要: |
| Objective To compare clinical effects, side effects and scores of living quality of late NHL treated by CTOP-P regimen and CHOP regimen.Method 72 late NHL patients who were admitted to this hospital from the year of 2009 to 2013 were divided into the treatment group and the control group by the random number table. 37cases of the treatment group was treated with CTOP-P regimen, 35 cases of the control group was treated with CHOP regimen. Clinical effects, side effects and scores of EORTC QLQ—C30 were compared after three courses of treatment.Result Efficacy of the two groups showed that clinical effects of the treatment group was better than the control group, and the differences were statistically significant(p<0.05) ; occurrence of side effects, such as gastrointestinalSreaction, hair loss,bone marrow suppression and cardiotoxicity, of the two groups showed that the treatment group was lower and the differences were significant(p<0.05); the scores of the treatment group were lower than the control group when compared the scores of physical functioning, role function, social function and cognitive function, which is lower when compared the scores of anorexia, nausea and vomiting, pain, dyspnea, insomnia and other discomforts, the differences of scores of EORTC QLQ—C30 of the two groups were significant(p<0.05).Conclusion CTOP-P regimen is an effective method and has less side effects, better tolerance of chemotherapy, which is deserved to be promoted clinically as a chemotherapy regimen of the late NHL. |
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