| 任洁,卢建华.RANKL/RANK/OPG系统与绝经后骨质疏松模型的研究[J].浙江中西医结合杂志,2015,25(9): |
| RANKL/RANK/OPG系统与绝经后骨质疏松模型的研究 |
| The study on RANKL/OPG/RANK system and model of postmenopausal osteoporosis |
| 投稿时间：2015-01-18 修订日期：2015-01-18 |
| DOI： |
| 中文关键词: RANKL/RANK/OPG 绝经后骨质疏松 护骨素 MiR-503 肿瘤坏死因子-а |
| 英文关键词:RANKL/OPG/RANK Postmenopausal osteoporosis Osteoprotegerin MiR - 503 Tumor necrosis factor-а |
| 基金项目:浙江省自然科学(No.Y206272) |
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| 中文摘要: |
| RANKL/RANK/OPG系统与绝经后骨质疏松发生发展密切相关。在骨吸收调节中,RANKL/RANK/OPG系统可识别不同的细胞调节因子,进而影响破骨细胞生成、分化和成熟。近年来,大量的RANKL/RANK/OPG系统方面的研究均集中在绝经后骨质疏松模型上进行。本文就绝经后骨质疏松模型、RANKL/RANK/OPG系统及其相关的细胞因子做一总结。 |
| 英文摘要: |
| RANKL/OPG/RANK system and postmenopausal osteoporosis in development are closely related. In bone resorption regulating, RANKL/OPG/RANK system can identify different cell regulatory factors, which affect osteoclast formation, differentiation and maturation.In recent years, a large number of RANKL/OPG/RANK system studies are focused on postmenopausal osteoporosis model. In this paper, the model of postmenopausal osteoporosis, RANKL/OPG/RANK system and its related cytokines are summarized. |
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