| 庆晓东,唐莉,郑俊青.乙酰谷酰胺注射液用于神经外科昏迷治疗的疗效及安全性研究[J].浙江中西医结合杂志,2015,25(11): |
| 乙酰谷酰胺注射液用于神经外科昏迷治疗的疗效及安全性研究 |
| The efficacy and safety of aceglutamide injection therapy for neurosurgical coma |
| 投稿时间：2015-01-23 修订日期：2015-09-16 |
| DOI： |
| 中文关键词: 重度颅脑损伤 昏迷 乙酰谷酰胺注射液 并发症 氨基酸 |
| 英文关键词:Severe traumatic brain injury coma Aceglutamide injection complications amino acids |
| 基金项目:河北省卫生厅课题：神经外科昏迷出院患者专科随访规范化探讨，编号：20130474 |
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| 中文摘要: |
| 目的：探讨乙酰谷酰胺注射液用于神经外科昏迷治疗的疗效及安全性。方法：重度颅脑损伤昏迷患者90例根据随机数字表法分为治疗组与对照组各45例,所有患者都给予急诊手术治疗,与此同时,入院后治疗组和对照组分别用不同的静脉点滴进行干预,分别是乙酰谷酰胺注射液以及生理盐水,持续干预7天。结果：术后3个月进行判定,治疗组与对照组的有效率分别为93.3%和73.3%,治疗组的有效率明显高于对照组(P<0.05)。术后经过3个月后,两组的GCS评分要比手术前高(P<0.05),其中,术后的GCS评分进行对比发现,对照组低于治疗组(P<0.05)。将两组谷氨酸与天冬氨酸含量进行比较,对照组高于治疗组(P<0.05),同时也明显低于术前(P<0.05)；手术前后对照组的谷氨酸及天冬氨酸含量对比差异无统计学意义。治疗组术后3个月期间的血管破裂、血栓形成、血管痉挛、过度灌注综合征等并发症发生情况明显低于对照组(P<0.05)。结论：乙酰谷酰胺注射液用于神经外科重型颅脑损伤昏迷患者的手术治疗能有效抑制兴奋性氨基酸的释放,减少对于神经功能的损伤,疗效可靠,且能减少并发症的发生,具有更好的安全性。 |
| 英文摘要: |
| Objective: To investigate the efficacy and safety of of aceglutamide injection therapy for neurosurgical coma. Methods: 90 coma with severe brain injury patients were randomly equally divided accorded to the treatment group and the control group, all patients were given emergency surgery, while the treatment group hospitalized were given the intravenous injection aceglutamide intervention, the control group were given the intravenous saline treatment, continued to intervene for 7 days. Results: After 3 months to determine, the response rates in the treatment group and the control group were 93.3% and 73.3%, respectively that the treatment group had significantly higher efficiency (P <0.05). Postoperative 3 months, the GCS scores were significantly higher than the preoperative GCS scores in the two groups(P <0.05), while the GCS scores in the treatment group were significantly higher Postoperative 3 months (P <0.05). The postoperative glutamic acid and aspartic acid contents in the treatment group were lower than the control group (P <0.05), but also were significantly lower than the preoperative (P <0.05); and the the control group compared wre showed no significant difference. Postoperative three-month periods, the complications of vascular rupture, thrombosis, vasospasm, hyperperfusion syndrome were significantly lower than the control group (P <0.05). Conclusion: Aceglutamide injection for neurosurgical surgery coma with severe brain injury patients can effectively inhibit the release of excitatory amino acids, reduce damage to nerve function, its effective and reliable, and can reduce the incidence of complications that have better security. |
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