| 徐晓翌,周素芳,赵桂侠,钟津津,王磊.益气养阴法对中晚期肺癌化疗患者近期生存质量的影响[J].浙江中西医结合杂志,2015,25(7): |
| 益气养阴法对中晚期肺癌化疗患者近期生存质量的影响 |
| The effect of Yiqi Yangyin method on the short-term quality of life of patients with advanced lung cancer receiving chemotherapy |
| 投稿时间：2015-02-05 修订日期：2015-03-30 |
| DOI： |
| 中文关键词: 非小细胞肺癌 益气养阴法 EORTC QLQ—LC43 生存质量 |
| 英文关键词:non-small cell lung cancer Yiqi Yangyin method EORTC QLQ—LC43 quality of life |
| 基金项目:浙江省卫生高层次人才培养工程医坛新秀培养计划(计划编号：2013245) |
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| 中文摘要: |
| 目的：通过欧洲癌症研究与治疗组织生命质量测定量表(EORTC QLQ—LC43)评估益气养阴法对中晚期非小细胞肺癌化疗患者近期生存质量的影响。方法：将41例患者随机分为2组，治疗组20例采用益气养阴法配合化疗；对照组单纯化疗。21d为1个疗程，连续治疗2个疗程，采用欧洲癌症研究与治疗组织生命质量测定量表(EORTC QLQ—LC43)进行生存质量评估。结果：治疗组治疗后各功能领域和总体健康状况领域评分均呈上升趋势，其中总健康状况评分与治疗前比较有显著性差异［（58.33±26.63）比（72.92±17.70），P＜0.05］；症状子量表领域及肺癌模块中绝大部分评分较治疗前呈降低趋势，提示症状减轻，其中疼痛［（22.50±23.12）比（7.50±10.08），P＜0.05］、气促［（26.67±31.72）比（8.33±14.81），P＜0.05］、失眠［（35.00±33.29）比（15.00±22.88），P＜0.05］等症状有显著性差异；对照组治疗后症状子量表领域中除疼痛、气促、腹泻外，评分均较治疗前呈上升趋势，提示症状加重，其中恶心呕吐［（3.97±8.98）比（29.37±32.45），P＜0.01］、食欲丧失［（30.16±25.62）比（53.97±32.45），P＜0.05］、便秘症状［（19.05±27.02）比（39.68±35.93），P＜0.05］有显著性差异；核心量表各领域除情绪、认知、社会功能及疲劳、疼痛、腹泻、经济困难外，治疗组与对照组在治疗后比较有显著性差异。肺癌模块中治疗组与对照组在治疗后咳嗽［（28.33±32.94）比（50.79±35.93），P＜0.05］、气促（散步时）［（29.99±28.41）比（52.38±34.27），P＜0.05］及周围神经病变［（6.67±13.68）比（20.63±24.67），P＜0.05］比较有显著性差异。结论：通过国际上广泛应用的测定量表(EORTC QLQ—LC43)，证实了益气养阴方配合化疗治疗中晚期非小细胞肺癌具有提高临床症状缓解率、改善生存质量等优点。 |
| 英文摘要: |
| Objective: To evaluate the effect of Yiqi Yangyin method on the short-term quality of life of patients with advanced lung cancer who receiving chemotherapy by European Organization for Research and Treatment of Cancer Quality of Life Questionary(EORTC QLQ—LC43). Methods: 41 cases of patients were divided into 2 groups, the treatment group received Yiqi Yangyin method plus chemotherapy; the control group received chemotherapy only.The course of treatment lasted 21 days, they received 2 courses, and the quality of life was evaluated by EORTC QLQ—LC43.Results: The scores of each function domain and the total health condition domain rose after treatment on treatment group, the difference of the score of the total health condition was significant［（58.33±26.63）比（72.92±17.70）,P＜0.05］; most of the scores in symptomatic domain and lung cancer module reduced, it meant the symptoms relieved, the differences with the pain［（22.50±23.12）比（7.50±10.08）,P＜0.05］, short of breath［（26.67±31.72）比（8.33±14.81）,P＜0.05］, insomnia［（35.00±33.29）比（15.00±22.88）,P＜0.05］ were significant; the scores of symptomatic domain after treatment on control group rose except the pain, short of breath, diarrhea, it meant the symptoms aggravated, the differences with the nausea and vomit［（3.97±8.98）比（29.37±32.45）,P＜0.01］, loss of appetite［（30.16±25.62）比（53.97±32.45）,P＜0.05］, constipation［（19.05±27.02）比（39.68±35.93）,P＜0.05］ were significant; except the emotion, recognition, social function and fatigue, pain, diarrhea, economic difficulty, the differences in each domain in central scale of the treatment group were significant compared with control group. In lung cancer module, the differences between cough［（28.33±32.94）比（50.79±35.93）,P＜0.05］, short of breath(walking) ［（29.99±28.41）比（52.38±34.27）,P＜0.05］ and peripheral neuropathy［（6.67±13.68）比（20.63±24.67）,P＜0.05］ in the treatment group were significant compared with control group.[Conclusion]: Yiqi Yangyin method plus chemotherapy on the treatment of advanced non-small cell lung cancer can relieve clinical syndromes and improve the quality of life. |
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