| 李诗国,戴圣伟,李群伟.地黄饮子胶囊联合盐酸多奈哌齐片治疗血管性痴呆57例临床观察[J].浙江中西医结合杂志,2015,25(7): |
| 地黄饮子胶囊联合盐酸多奈哌齐片治疗血管性痴呆57例临床观察 |
| Clinical Observation on Dihuang Yizhi capsule Combined With Donepezil for 57 patients with Vascular DementiaLi Shiguo, Dai Shengwei, Li Qunwei |
| 投稿时间：2015-02-22 修订日期：2015-03-30 |
| DOI： |
| 中文关键词: 血管性痴呆 肾精亏虚兼痰瘀阻络 盐酸多奈哌齐片 |
| 英文关键词:vascular dementia kidney-essence deficiency and phlegm-stasis obstructing network vessels pattern Donepezil |
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| 中文摘要: |
| ［］ 目的 观察地黄饮子胶囊联合盐酸多奈哌齐片治疗血管性痴呆肾精亏虚兼痰瘀阻络证的临床疗效及安全性。方法 将110例血管性痴呆肾精亏虚兼痰瘀阻络证患者随机分为观察组57例与对照组53例,对照组给予盐酸多奈哌齐片,每次5～10mg,每日1次口服。观察组在对照组基础上加用地黄饮子胶囊,每次2g,每日2次口服。两组均以30天为一个疗程。治疗6个疗程。两组于治疗前后采用简易精神状态检查表(MMSE)评价患者认知功能,采用Blessed行为量表(BBS评分)评价患者行为能力,采用中医症状积分量表评价临床疗效。结果 观察组中医证候总有效率为75.44%,对照组中医证候总有效率为58.59%,两组比较差异显著(P＜0.05)。治疗后两组MMSE评分升高,BBS评分及中医症状积分降低,差异有统计学意义(P＜0.05或P＜0.01),治疗后两组间比较,各量表评分差异有统计学意义(P＜0.05或P＜0.01)。结论 地黄饮子胶囊联合盐酸多奈哌齐片治疗血管性痴呆肾精亏虚兼痰瘀阻络证能明显提高患者认知能力,改善临床症状及日常生活能力,优于单用盐酸多奈哌齐片,两组均无不良反应。 |
| 英文摘要: |
| Objective To observe the efficacy and safety of Dihuang Yinzi capsule combined with Donepezil for vascular dementia patients with kidney-essence deficiency and phlegm-stasis obstructing network vessels pattern. Methods Totally 110 vascular dementia patients with kidney-essence deficiency and phlegm-stasis obstructing network vessels pattern were randomized into the observation group and control group, with 57 and 53 in each. The control group was given 5～10mg Donepezil Tablet once daily. The observation group was added with 2mg Dihuang Yinzi capsule twice daily. The treatment lasted for 6 months. The therapeutic effect was observed. Mini-Mental State Examination (MMSE) was used to evaluate cognitive function, Blessed Behavior Score (BBS) was used to evaluate behavior ability, and TCM Symptom Score Scale was used to evaluate clinical efficacy. Result The total efficacy of TCM syndrome in the observation group and control group was 75.44% and 58.59% respectively, with a significant difference between groups (P＜0.05).The scores of MMSE was significantly increased but the scores of BBS and TCM syndrome ware significantly decreased in both groups after treatment (P＜0.05 or P＜0.01)， especially in the observation group (P＜0.05 or P＜0.01). Conclusion Dihuang Yinzi capsule combined with Donepezil for vascular dementia patients with kidney-essence deficiency and phlegm-stasis obstructing network vessels pattern can obviously increase the cognitive ability, relieve the clinical symptoms, with a better efficacy as compared with single application of Donepezil, there was no adverse reaction in both groups. |
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