| 姜春晓.止痛四物汤对肾虚血瘀型膝关节骨性关节炎患者血清肿瘤坏死因子-α和白介素-10水平的影响及疗效观察[J].浙江中西医结合杂志,2015,25(9): |
| 止痛四物汤对肾虚血瘀型膝关节骨性关节炎患者血清肿瘤坏死因子-α和白介素-10水平的影响及疗效观察 |
| Influence and Curative Effect Observation of Zhitong Siwu Decoction on Serum Tumor Necrosis Factor-α (TNF-α) and Interleukin-10 (IL-10) Levels in synovial fluid of patients with Knee Osteoarthritis (OA) |
| 投稿时间：2015-03-24 修订日期：2015-04-24 |
| DOI： |
| 中文关键词: 骨性关节炎 膝关节 止痛四物汤 肿瘤坏死因子-α 白介素-10 |
| 英文关键词:Osteoarthritis (OA) Knee Zhitong Siwu Decoction Tumor Necrosis Factor-α (TNF-α) Interleukin-10 (IL-10) |
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| 中文摘要: |
| 目的：探讨止痛四物汤对肾虚血瘀型膝关节骨性关节炎患者血清肿瘤坏死因子-α(TNF-α)和白介素-10(IL-10)水平的影响及疗效观察。方法：选择骨伤科就诊的肾虚血瘀型膝关节OA患者78例,随机分为研究组和对照组。对照组患者予以盐酸氨基葡萄糖胶囊1粒/次,2次/d,连用6周。研究组患者加用止痛四物汤口服,1剂/d,水煎300ml,分早晚两次口服,连用6周。观察并记录两组治疗前和治疗6周后血清TNF-α和IL-10水平的变化,并比较其临床效果及药物不良反应情况。结果：治疗6周后,两组患者血清TNF-α水平较前有明显下降(P<0.05或P<0.01),血清IL-10水平较前明显上升(P<0.05或P<0.01),且研究组下降或上升值较对照组更明显(P<0.05)；研究组患者的临床总有效率为94.87%,明显高于对照组的79.49 %(χ2 =4.13,P<0.05)；两组患者共发生不良反应14例,其中对照组6例,研究组8例,症状较轻微,两组比较差异无统计学意义(χ2 =0.35,P>0.05)。结论：止痛四物汤治疗肾虚血瘀型膝关节OA的具有较好的疗效及安全性,能降低血清TNF-α水平,升高血清IL-10水平,从而调节血清促炎症因子/抗炎症因子的比例,从而抑制关节局部炎症反应,减少对软骨细胞和软骨基质的的破坏密切相关。 |
| 英文摘要: |
| [Abstract]Objective: To discuss influence and curative effect observation of Zhitong Siwu Decoction on serum tumor necrosis factor-α (TNF-α) and interleukin-10 (IL-10) levels in synovialfluid of patients with knee osteoarthritis (OA).Methods: 78 cases in synovialfluid of patients with Knee OA, who were given the medical treatment in Department of Orthopedics, were selected and divided into research group and control group at random. The patients in control group were given Glucosamine Hydrochloride Capsules, one tablet per time, twice a day for 6 weeks, while the patients in research group were additionally given Zhitong Siwu Decoction, one dose a day, 300ml decocted with water, through the mouth for day and night, for 6 weeks. The changes of serum TNF-α and IL-10 levels of patients in two groups before and 6 weeks after the medical treatment were observed and recorded, and the clinical curative effect and drug adverse reaction (DAR) were compared as well. Results: After 6 weeks’ medical treatment, serum TNF-α level of patients in two groups obviously declined than before (P<0.05 or P<0.01), while serum IL-10 level obviously rose than before (P<0.05 or P<0.01), and the declining or rising rate in research group were much higher than those in control group (P<0.05). The total clinical efficiency of patients in research group was 94.87%, which was much higher than that in control group (79.49?%) (χ2?=4.13, P<0.05). 14 cases of untoward effect appeared on patients in two groups, including 6 and 8 cases in control group and research group respectively, with light symptom, and no statistical differences appeared after comparison (χ2=0.35, P>0.05). Conclusion: has favorable curative effect and security in synovialfluid of patients on knee OA, and can reduce serum TNF-α level and raise serum IL-10 level, which has close effect on adjusting the proportion of serum proinflammatory cytokines and anti-inflammatory factors, restraining local joint inflammation and reducing destroy of cartilage cells and mesochondrium. |
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