| 金水芳,虞玉群,江荣林.电针对脓毒症患者炎症细胞因子的影响[J].浙江中西医结合杂志,2016,26(2): |
| 电针对脓毒症患者炎症细胞因子的影响 |
| Effects of electro-acupuncture on inflammatory cytokines in patients with sepsis |
| 投稿时间：2015-03-28 修订日期：2015-05-20 |
| DOI： |
| 中文关键词: 脓毒症 电针 肿瘤坏死因子-α 白细胞介素-6 白细胞介素-10 |
| 英文关键词:sepsis electro-acupuncture tumor necrosis factor-α interleukin-6 interleukin-10 |
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| 中文摘要: |
| 目的 观测电针刺激对脓毒症患者炎症细胞因子的影响。方法 将43例脓毒症患者随机分为电针组(23例)和对照组(20例),对照组常规治疗,电针组在对照组的基础上每日接受电针治疗。一个疗程后采用酶联免疫吸附法(ELISA)测定血清TNF-α、IL-6及IL-10水平,并同时记录患者急性生理学与慢性健康状况评分系统(APACHEⅡ)评分。结果 两组患者治疗前APACHEⅡ评分以及TNF-α、IL-6、IL-10水平差异无统计学意义(P>0.05)。经治疗后,两组患者APACHEⅡ评分以及TNF-α、IL-6、IL-10水平均有降低,但电针组APACHEⅡ评分以及TNF-α、IL-6水平更明显,差异有统计学意义(P<0.05)。结论 电针刺激能降低脓毒症患者TNF-α、IL-6水平,抑制炎症反应,改善患者临床症状,降低APACHEⅡ评分,其作用机制可能与其调节脓毒症患者促炎/抗炎细胞因子的平衡有关。 |
| 英文摘要: |
| Objective To investigate the effects of electro-acupuncture on inflammatory cytokines in patients with sepsis. Methods Forty-three patients with sepsis were randomly divided into the electro-acupuncture group (23 cases) and control group (20 cases). Control group received routine treatment, while the electro-acupuncture group received daily electro-acupuncture treatment in addition to the routine treatment of the control group. Serum levels of tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6) and interleukin-10 (IL-10) were determined by enzyme-linked immunosorbent assay (ELISA) after a period of treatment, and acute physiology and chronic health evaluation Ⅱ (APACHEⅡ) score was also recorded. Results APACHEⅡ score and serum levels of TNF-α, IL-6 and IL-10 were similar between two groups before treatment (P>0.05). All the indicators were decreased in both groups after treatment. However, the electro-acupuncture group had a lower APACHEⅡ score, TNF-α and IL-6 levels, and the difference was statistically significant (P<0.05). Conclusions Electro-acupuncture can reduce TNF-α and IL-6 levels, inhibiting inflammatory reaction, improving clinical symptoms and reducing the APACHEⅡ score in patients with sepsis. Its mechanism may be related to regulation of pro-inflammatory/anti-inflammatory cytokines balance in patients with sepsis. |
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