| 武利强,林圣云,胡致平,叶宝东,沈建平,周郁鸿.达那唑、阿赛松联合中药参血胶囊治疗难治免疫性血小板减少症疗效观察[J].浙江中西医结合杂志,2015,25(12): |
| 达那唑、阿赛松联合中药参血胶囊治疗难治免疫性血小板减少症疗效观察 |
| The observation of curative effect of Danazol and triamcinolone combined with Shenxue capsule in the treatment of Refractory immune thrombocytopeniaWu Liqiang, Lin Shengyun, Hu Zhiping, Ye Baodong, Lin Xiaojie, Shen Jianping,Zhou Yuhong. |
| 投稿时间：2015-04-25 修订日期：2015-06-18 |
| DOI： |
| 中文关键词: 难治性ITP 达那唑 参血胶囊 调节T细胞 |
| 英文关键词:Refractory ITP Danazl Shenxue capsule Regulatory T cells |
| 基金项目:科技部“十一五”国家科技支撑计划 |
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| 中文摘要: |
| 目的:观察达那唑、阿赛松联合中药参血胶囊治疗难治免疫性血小板减少症的疗效对其机制进行探讨。方法:65例入组患者分为达那唑联合阿赛松治疗组与达那唑联合阿赛松及参血胶囊治疗组分别进行统计。达那唑、阿赛松治疗组:达那唑5mg/(kg.d)(0.2-0.4/d)、阿赛松0.5mg/(kg.d)(24mg-36mg/d); 达那唑、阿赛松联合参血胶囊组:达那唑、阿赛松用法同上,同时再给予中药参血胶囊1.4/d,分2次口服; 两组治疗观察时间均为4个月,检测各组患者治疗前后CD4+CD25+细胞和CD4+CD25+Foxp3+细胞的表达水平。结果:达那唑联合阿赛松治疗组有效率31.2%,达那唑联合阿赛松及参血胶囊治疗组有效率57.6%。两组差异有显著统计学意义( |
| 英文摘要: |
| [Objective] To investigate the effect and mechanism of Danazol, Triamcinolone Tablets combined with traditional Chinese medicine Shenxue capsule in the treatment of refractory immune thrombocytopenia(ITP).[Method] The 65 patients were randomly divided into two groups :Danazol combined Triamcinolone Tablets group and Shenxue capsule was added group. Danazol combined Triamcinolone Tablets group : Danazol Triamcinolone Tablets was used as 5mg/ (kg.d) (0.2-0.4/d), Triamcinolone Tablets was used as 0.5mg/ (kg.d) (24mg-36mg/d); Shenxue capsule was added group: Danazol、Triamcinolone Tablets were reused as the same dose, at the same time give Shenxue capsule 1.4g/d. The observation time was four months. The expressions of CD4+CD25+cells and CD4+CD25+Foxp3+ cells were detected by flow cytometry.[Result] The effective rates were31.2% and57.6% in the treatment group of Danazol combined Triamcinolone and Danazol、Triamcinolone combined Shenxue capsule respectively; the overall effective rates were 44.6%.The difference was significant between two groups (P<0.05). The ratio of CD4+CD25+cells and CD4+CD25+Foxp3+cells in patients with refractory ITP were significantly reduced(p<0.05) compared with the health groups..The two groups of patients with regulatory T cells expression levels were increased after treatment, there was no significant difference between the two groups.[Conclusion] The study showed that Treg cells in the patients with refractory ITP may be one reason of refractory ITP. The treatment of Danazol combined Triamcinolone could improve the expression level of regulatory T cells in the patients with refractory ITP, and have an high efficiency. If combined with traditional Chinese medicine Shengxue capsule can further improve the effective rate but not increase the the side effects of drugs. |
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