| 冯珺,曹佳薇,姚君,周峰,蔡鑫君,倪坚军.生脉注射液与常用输液配伍稳定性的研究[J].浙江中西医结合杂志,2016,26(1): |
| 生脉注射液与常用输液配伍稳定性的研究 |
| Graduate compatible stability of Shengmai injection with common infusion fluids FENG Jun ,CAO Jiawei,YAO Jun,ZHOU Feng,CAI Xingjun,NI Jianjun. |
| 投稿时间：2015-07-15 修订日期：2015-08-19 |
| DOI： |
| 中文关键词: 生脉注射液 输液配伍 稳定性 |
| 英文关键词:Shengmai infusions matching stability |
| 基金项目:浙江省中西医结合学会科研项目(2012LY017) |
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| 中文摘要: |
| 目的：考察生脉注射液在5%葡萄糖注射液和0.9%氯化钠注射液中的配伍稳定性。方法：将生脉注射液按临床常规剂量与2种输液配伍,在室温条件下放置5 h,用HPLC法测定配伍后不同时间点的人参皂苷Rg1含量,并观察配伍溶液的外观形状,测定不溶性微粒数目。结果：生脉注射液与2种输液配伍后,其外观无显著性改变；配伍后注射液中的微粒数随放置时间延长而增多；与5%葡萄糖注射液配伍1 h后人参皂苷Rg1含量明显下降,与0.9%NS 250 ml注射液配伍5 h内人参皂苷Rg1含量基本不变。结论：与5%葡萄糖注射液相比,生脉注射液在0.9%NS注射液的稳定性更好,同时也适合糖尿病患者临床应用。 |
| 英文摘要: |
| ABSTRACT: OBJECTIVE:To study the compatible stability of Shengmai injecion in 5%Glucose Injection or 0.9% Sodium chloride injection. METHODS:A clinical routine dose of Shengmai injection was added to each of the two infusion fluids, and the mixtures were kept at room temperature for 5h. The contents of ginsenoside Rg1 were determined at different time points by HPLC. The appearance and insoluble particles of the mixed solution were detected. RESULTS: Shengmai injection combined with 2 kinds of infusion, its appearance had no significant change; The number of particles with the time were prolonging; The contents of ginsenoside Rg1 in 5% Glucose Injection were decreased significantly after 1h, but the contents of ginsenoside Rg1 in 0.9%NS 250ml were hardly changed.CONCLUSION: Compared with 5% glucose injection, the stability of 0.9%NS injection is better, and it is suitable for the clinical application of diabetic patients. |
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