| 邢现峰.肝硬化并感染性休克患者的病原菌谱及耐药性分析[J].浙江中西医结合杂志,2016,26(3): |
| 肝硬化并感染性休克患者的病原菌谱及耐药性分析 |
| Pathogenic Bacteria Spectrumand Drug resistance analysisIsolated from Cirrhosis patients with Septic Shock |
| 投稿时间：2015-08-05 修订日期：2015-08-05 |
| DOI： |
| 中文关键词: 肝硬化 感染性休克 病原菌 耐药性 |
| 英文关键词: |
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| 中文摘要: |
| 【】 目的 肝硬化是临床上较为常见的慢性肝病。分析肝硬化并感染性休克患者的病原菌谱及耐药情况,指导临床药物治疗,提高治疗效果,可大大增加肝硬化患者的存活及向恶性发展的趋势。方法 选取本院2010年1月～2015年2月166例肝硬化并感染性休克患者情况进行回顾性分析,采用法国VITEK32全自动细菌检定仪对分离菌株进行鉴定,药敏实验采用K-B法。结果 共分离出182株病原菌,主要是大肠埃希菌(46.2%)、肺炎克雷伯菌(17.7%)、金黄色葡萄球菌(6.6%)、肠球菌(2.7%)等,都是多种药物的耐药菌； 真菌类病原体多为曲霉菌、白色念球菌。病原菌最容易在腹腔(47.2%)、痰液(33.5%)、血液(15.4%)等分布。结论 肝硬化并感染性休克患者最常见感染病原菌为大肠埃希菌和肺炎克雷伯菌,且多为耐药菌株,在肝硬化感染性休克的患者中可根据可能的感染病原菌给予经验性治疗,对决定预后会有重要意义。 |
| 英文摘要: |
| 【】 Objective Liver cirrhosis is a more common chronic liver disease in clinical, and it is a diffuse liver injury which formed repeatedly for long time by one and more causes. To investigate the epidemiology of bacterial infection in patients of cirrhosis associated with septic shock and analyze the antimicrobial susceptibility of their major pathogens. Methods A retrospective survey was conducted in 166 patients of cirrhosis associated with septic shock admitted in the xxxx Hospital of xxxx from Jan. 2010 to Feb. 2010. Identification and susceptibility of pathogens were respectively determined by France VITEK32 Automatic Bacteria Test Instrument and K-B method. Results Totally 182 straints of pathogens were isolated from spicemens of cirrhosis patients with septic shock. The pathogen bacterias mainly consisted of Escherichia coli(46.2%), Klebsiella pneumoniae(17.7%), Staphylococcus aureus(6.6%) and Enterococcus faecalis(2.7%), all of which were multi-drug-resistant.Fungal pathogen mainly consisted of Aspergillus and Candida albicans. The infection was frequently identified in sputum(33.5%), blood stream(15.4%), intra-abdominal cavity(47.2%) and etc. Conclusion The main Pathogen of liver cirrhosis patients with septic shock are Escherichia coli and Klebsiella pneumoniae. And most of Pathogen are multi-drug-resistant.So the detection of pathogenic bacteria in clinical treatment has important significance. |
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