| 余峰.IL-23/Th17轴与银屑病[J].浙江中西医结合杂志,2016,26(4): |
| IL-23/Th17轴与银屑病 |
| The IL-23/Th17 Axis in Psoriasis |
| 投稿时间：2015-08-07 修订日期：2015-10-20 |
| DOI： |
| 中文关键词: 白介素-23,Th17,银屑病 |
| 英文关键词:IL-23 Th17 psoriasis |
| 基金项目: |
|
| 摘要点击次数: 1347 |
| 全文下载次数: 77 |
| 中文摘要: |
| 炎症介质的异常产生在银屑病的发病机理中起着重要作用。近年来无论是小鼠还是人的研究都聚焦于一种新的T辅助细胞亚型,它以产生IL-17为主要特点,因此被命名为Th17细胞。本文对人Th17细胞的特点及功能,以及IL-23在Th17细胞依赖的银屑病慢性炎症中的重要作用进行综述,并介绍新近的IL-23/Th17轴靶向治疗银屑病的临床试验。 |
| 英文摘要: |
| Abnormal production of inflammatory mediators is believed to play an important role in the pathogenesis of psoriasis. Emerging data, both in mice and in humans, put the spotlight on a new subset of T helper (Th) cells, in part characterized by their production of IL-17 and accordingly named Th17 cells. Here, we review the characterization and function of human Th17 cells as well as the crucial role of IL-23 in the context of Th17-cell-dependent chronic inflammation in psoriasis. We further introduce the recent clinical trials targeting the IL-23/Th17 axis in psoriasis. |
| 查看全文 查看/发表评论 下载PDF阅读器 |
| 关闭 |
|
|
|
