| 俞红琴,李诗国,吕艳叶.丹红注射液对活动期类风湿关节炎患者白细胞介素-1、6及肿瘤坏死因子α的影响[J].浙江中西医结合杂志,2016,26(4): |
| 丹红注射液对活动期类风湿关节炎患者白细胞介素-1、6及肿瘤坏死因子α的影响 |
| SEfficacy of Danhong injection for patients with active rheumatoid arthritis and its effects on serum levels of interleukin-1, interleukin-6 and tumor necrosis factor-α |
| 投稿时间：2015-09-02 修订日期：2016-02-03 |
| DOI： |
| 中文关键词: 丹红注射液 类风湿关节炎 肿瘤坏死因子 白细胞介素1 白细胞介素6 |
| 英文关键词:Danhong injection rheumatoid arthritis tumor necrosis factor-α interleukin-1 interleukin-6 |
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| 中文摘要: |
| 目的 探讨丹红注射液对活动期类风湿关节炎的疗效及其对白细胞介素-1、6及肿瘤坏死因子α的影响。方法 将138例活动期类风湿关节炎患者随机分为观察组92例与对照组46例,对照组给予以常规治疗：甲氨蝶呤片10mg,每周1次；来氟米特片10mg,每日1次；双氯芬酸钠肠溶缓释胶囊100mg,每日1次等治疗。观察组在常规治疗基础上,给予丹红注射液20ml,加入5%葡萄糖250ml静滴,每日1次,20天为一个疗程,间隔10天后进行第二个疗程。两组均治疗3个月后观察临床疗效,比较治疗前后关节肿胀数(SJC28)、关节压痛数(TJC28)、晨僵时间等变化,进行患者疼痛评分,检测类风湿因子(RF)、血沉(ESR)、C反应蛋白(CRP)、肿瘤坏死因子(TNF-α)、白细胞介素1(IL-1)及白细胞介素6(IL-6)等治疗前后的变化。结果 观察组总有效率93.48%；对照组总有效率86.96%,两组总有效率比较有显著性差异(P＜0.05)。治疗后两组的SJC28、TJC28、患者疼痛评分、晨僵时间均明显下降(P＜0．01或P＜0．05)；治疗后观察组与对照组比较,差异有显著性(P＜0．01或P＜0．05)。治疗后两组的ESR、CRP、RF均明显下降(P＜0．01或P＜0．05)；治疗后观察组与对照组比较,差异有显著性(P＜0．01或P＜0．05)。治疗后两组的IL-1、IL-6、TNF-α均明显下降(P＜0．01或P＜0．05)；治疗后观察组与对照组比较,差异有显著性(P＜0．01或P＜0．05)。结论 丹红注射液可下调活动期类风湿关节炎IL-1、IL-6和TNF-α,从而抑制免疫炎症反应,达到治疗活动期类风湿关节炎的目的。 |
| 英文摘要: |
| ABSTRACT Objective To evaluate efficacy of Danhong injection for patients with active rheumatoid arthritis and its effects on serum levels of interleukin-1 (IL-1), interleukin-6 （IL-6） and tumor necrosis factor-α （TNF-α）. Methods 138 patients with active rheumatoid arthritis were randomized into the observation group and control group, with 92 and 46 in each. The control group was given 10mg of methotrexate tablets (MTX) once weekly, 10mg leflunomide tablets and 10mg diclofenac sodium enteric-coated sustained release capsules once daily. The observation group was added with 20ml of Danhong injection in 250ml of 5% glucose intravenous drip once daily, 20 days for a course of treatment, 10 days after the second course of treatment. The treatment of both groups lasted for 3 months. The efficacy was observed, The Swollen Joint Count 28 (SJC28), Tender Joint Count 28 (TJC28), time of morning stiffness (TMS) were compared. The pain score was observed. The rheumatoid factors (RF), erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), interleukin-1 (IL-1), interleukin-6 （IL-6）, tumor necrosis factor-α （TNF-α） were detected before and after treatment. Result The total effective rate of the observation group and control group was 93.48% and 86.96% respectively. with a significant difference between groups (P＜0.05). The SJC28，TJC28，TMS ，pain score ，RF ，ESR ，CRP ，IL-1，IL-6，TNF-α in both groups were significantly decreased after treatment (P＜0.01 or P＜0.05), especially in the observation group (P＜0.01 or P＜0.05). Conclusion Danhong injection can reduce the levels of IL-1、IL-6 and TNF-α to suppress the immune inflammatory reaction so as to treat active rheumatoid arthritis. |
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