| 张艳,吴春丽,瞿镔,裘新民,梁丽贞,严永兴.260例治疗失败梅毒患者血、脑脊液IL-6,IL-10,TNF-a检测结果分析[J].浙江中西医结合杂志,2016,26(4): |
| 260例治疗失败梅毒患者血、脑脊液IL-6,IL-10,TNF-a检测结果分析 |
| Analysis of serum and cerebrospinal fluid (CSF) levels of IL-6,IL-10 and TNF-a in 260 syphilis patients with treatment failureZhang Yan,Wu Chunli, Qu Bin,Qiu Xinming,Liang Lizhen, Yan Yongxing |
| 投稿时间：2015-11-05 修订日期：2015-12-10 |
| DOI： |
| 中文关键词: 梅毒 白介素－6 白介素－10 肿瘤坏死因子－a |
| 英文关键词:syphilis interleukin 6 interleukin 10 tumor necrosis factor-a |
| 基金项目:杭州市医药卫生计划项目(2012A032)；杭州市医学重点专科专病项目(20110733Q27) |
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| 中文摘要: |
| 目的：分析经驱梅治疗失败梅毒患者血、脑脊液IL-6、IL-10、TNF-a水平,探讨其在病程中免疫应答的变化。方法：采用双抗体夹心酶联免疫吸附试验法检测260例治疗失败梅毒患者、52例治疗后血清转阴梅毒患者、30例健康人血清细胞因子IL-6、IL-10、TNF-a水平,同时对260例治疗失败梅毒患者腰穿,进行脑脊液IL-6、IL-10、TNF-a、TPPA、VDRL、FTA-ABS检测,并对检测结果进行对比分析。结果：治疗失败组患者血清IL-6、IL-10、TNF-a水平显著高于治疗后阴转组(P ＜0.05)及正常对照组(P＜0.01)；治疗后阴转组患者血清IL-6、IL-10、TNF-a水平高于正常对照组,但无统计学差异(P＞0.05)。260例治疗失败梅毒患者确诊神经梅毒41例,其血清、脑脊液IL-6、IL-10、TNF-a水平显著高于非神经梅毒患者组(P＜0.01)。结论：细胞因子IL-6,IL-10,TNF-a参与了梅毒的发病、发展过程,随着病程进展细胞免疫功能受到一定抑制。 |
| 英文摘要: |
| Objective: To analyze the serum and cerebrospinal fluid levels of IL-6, IL-10 and TNF-a in syphilis patients with treatment failure, and to investigate the changes of immune response in the course of disease progression. Methods: Double antibody sandwich enzyme linked immunosorbent assay was used to detect the serum levels of IL-6, IL-10 and TNF-a in 260 syphilis patients with treatment failure,52 syphilis patients with seronegative after treatment and 30 healthy subjects.260 cases of syphilis patients with treatment failure were received lumbar puncture for |
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