| 熊静芳,傅国胜.阿托伐他汀联合拜阿司匹林对缺血性脑卒中患者颈动脉斑块及卒中复发的影响。[J].浙江中西医结合杂志,2016,26(4): |
| 阿托伐他汀联合拜阿司匹林对缺血性脑卒中患者颈动脉斑块及卒中复发的影响。 |
| Hangzhou 310003, Department of Geriatrics, Hangzhou Red Cross Hospital (XIONG Jing-fang, NIE Jing, SUN Wen-li, PANG Yu-ping, LI Juan)Hangzhou 310020, Department of Cardiology, Zhejiang University Medical College Affiliated Sir Run Shaw Hospital(FU Guo-sheng) |
| 投稿时间：2015-11-13 修订日期：2015-12-21 |
| DOI： |
| 中文关键词: 阿托伐他汀 阿司匹林 缺血性脑卒中 颈动脉斑块 复发 |
| 英文关键词:Atorvastatin Aspirin Cerebral infarction Carotid plaque Recurrence of cerebral infarction |
| 基金项目:国家自然科学基金(81070163) |
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| 中文摘要: |
| 【】 目的 观察阿托伐他汀联合拜阿司匹林对缺血性脑卒中患者颈动脉斑块以及卒中复发的影响。 方法 将70例存在颈动脉斑块的缺血性脑卒中患者随机分为两组,每组均为35例,均于治疗前及治疗12个月后检查颈动脉CTA。治疗组口服阿托伐他汀钙片及阿司匹林肠溶片；对照组口服阿司匹林肠溶片。治疗12个月后分析阿托伐他汀联合拜阿司匹林组对缺血性脑卒中患者颈动脉斑块性质、面积及狭窄程度、血脂变化及卒中复发的影响,并作统计学分析。结果 治疗12个月后治疗组不稳定斑块率下降,斑块面积缩小,管腔狭窄率下降,总胆固醇以及低密度脂蛋白胆固醇水平下降,与治疗前相比差异有统计学意义(P <0.05),与对照组相比差异有统计学意义(P <0.05)；治疗组12个月内缺血性脑卒中复发率小,与对照组相比差异有统计学意义(P <0.05)。结论 阿托伐他汀联合拜阿司匹林能够稳定颈动脉斑块、减少12个月内卒中复发。 |
| 英文摘要: |
| 【】 Objective To evaluate the influence of combined therapy of atorvastatin and aspirin on carotid plaques in patients with cerebral infarction and the recurrence of cerebral infarction. Methods 70 cerebral infarction patients with carotid plaque were randomly divided into two groups with each group 35 cases. Carotid CT angiography was checked before treatment and after 12 months of treatment. The patients in treatment group received combined therapy of atorvastatin and aspirin enteric-coated tablets, while patients in the control group took aspirin enteric coated tablet only. The effects of atorvastatin and aspirin treatment on carotid plaques, degree of carotid artery luminal narrowing, blood lipid level and recurrence of cerebral infarction were evaluated after 12 months of treatment. Results Unstable plaques rate, plaque area and the degree of carotid artery luminal narrowing reduced, and the levels of total cholesterol and low density lipoprotein cholesterol reduced in treatment group after 12 months of treatment. There were significant differences compared with pre-therapy as well as with control group with P value grater than 0.05. The recurrence rate of cerebral infarction within 12 months in treatment group significantly reduced compared to the control group with P value grater than 0.05. Conclusion The combined therapy of atorvastatin and aspirin enteric-coated tablets could stabilize carotid plaque and reduce the recurrence rate of cerebral infarction within 12 months. |
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