| 刘显鹏,苏卫东.温州地区335例新生儿肺炎病原菌及耐药性分析[J].浙江中西医结合杂志,2016,26(11): |
| 温州地区335例新生儿肺炎病原菌及耐药性分析 |
| Distribution and Antibiotic Resistance of Pathogens from 335 Neonates with PneumoniaLiu Xianpeng, Huang Yudan, Xue Huifen, Jiang Yi,Su Weidong |
| 投稿时间：2016-03-21 修订日期：2016-08-30 |
| DOI： |
| 中文关键词: 新生儿 肺炎 病原菌 耐药性 |
| 英文关键词:Neonate Pneumonia Pathogens Resistance |
| 基金项目: |
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| 中文摘要: |
| 目的 探讨新生儿肺炎病原菌的分布特点及其耐药性,以指导临床合理选择抗生素。方法 收集335例新生儿肺炎患儿的痰标本进行细菌培养并检测其对抗生素的耐药性,并对革兰阴性杆菌进行ESBLs检测。结果 从335例痰液病原菌培养标本中分离出病原菌223株,培养阳性率为66.6%。其中革兰阳性菌62株,占27.8%；革兰阴性菌152株,占68.2%(其中ESBLs 61珠,占革兰阴性菌40.1%)；真菌9株,占4.0%。ESBLs产酶珠对氨苄西林、头孢唑林、米诺环素、阿莫西林克拉维酸钾等耐药性高,对美罗培南、亚胺培南敏感性好。革兰阳性菌对青霉素、氨苄西林、红霉素及夫西地酸耐药率高,对万古霉素敏感性好。结论 革兰阴性菌是引起新生儿肺炎的常见病原菌,加强病原菌培养及耐药性检测对合理选择抗生素有重要意义。 |
| 英文摘要: |
| Objective To study the clinical distribution and drug resistance characteristics of pathogens causing neonatal pneumonia, and to provide the guidance for clinical therapy. Methods Sputum specimen were gathered from 335 neonates with pneumonia.Pathogens isolation and drug resistance tests were performed. Results Among 335 pathogenic strains,223(66.6%) were identified,including 62(27.8%) of Gram-positive bacilli, 152(68.2%) of Gram-negative bacilli-about 61(40.1%) Gram-negative bacilli produced ESBLs, and 9(4%) of fungi.ESBLs-producing bacilli were highly resistant to ampicillin, cefazolin,minocycline and amoxicillin-clavulanicacid.And susceptible to meropenem, imipenem.Gram-positive bacilli were highly resistant to penicillin, ampicillin, erythromycin and fusidic acid.And susceptible to vancomycin. Conclusion Cram-negative bacilli are the main pathogens of pneumonia in neonates.Pathogens isolation and drug resistance are important in selecting antimicrobial. |
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