| 赵娜,邓旻.肠道菌群移位对MODS发生发展的影响及其防治[J].浙江中西医结合杂志,2017,27(2): |
| 肠道菌群移位对MODS发生发展的影响及其防治 |
| Prevention and curing of intestinal bacterial translocation andits influence to the occurrence and development of MODS |
| 投稿时间：2016-04-27 修订日期：2016-04-27 |
| DOI： |
| 中文关键词: 正常菌群 肠道菌群移位 内毒素移位 多脏器功能衰竭 |
| 英文关键词:normal flora bacterial translocation endotoxin translocation MODS |
| 基金项目:杭州市科技局科技计划项目2015YD27 |
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| 中文摘要: |
| 人体肠道中储存的种类繁多的微生物共同构成了人体肠道的微生态环境,在正常情况下,肠道微生态处于平衡状态,肠道微生物与人体保持互利共生关系,但是当机体遭受强烈损害而处于应激状态时,肠道内蓄积的微生物失衡、细菌或其释放产物内毒素移位均可对炎症介质持续起着激惹作用,导致大量炎症介质的释放,造成内源性的感染,参与SIRS(systemic inflammatory response syndrome,SIRS)/MODS(multiple organ dysfunction syndrome,MODS)的发生发展,因此,肠道是炎症细胞激活、炎症介质释放的重要场地之一,也是MODS的源地之一,积极预防纠正肠道微生态失衡于MODS治疗及预后有着重要意义。 |
| 英文摘要: |
| A wide variety of microorganisms stored in human intestinal tract collectively constitute the micro-ecological environment of human intestinal tract. Under normal circumstances, the intestinal micro-ecology is in equilibrium where there is mutualism between the intestinal microorganisms and human body. But when human body is in stress state due to strong damages, intestinal microorganism imbalance and the translocation of bacteria or toxin released from the products may constantly have irritation effect on inflammatory mediators, resulting in releasing large amount of inflammatory mediators, causing endogenous infection and participating in the occurrence and development of MIRS/MODS. Therefore, intestinal tract is one of the most important places for inflammatory cell activation and release of inflammatory mediators as well as a source of MODS. Actively preventing and correcting intestinal micro-ecological imbalance is of great significance in the treatment and prognosis of MODS. |
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