| 施晨璐,张云鹏,陶茂灿.整合素相互作用蛋白Kindlin家族与表皮干细胞增殖分化的相关性研究进展[J].浙江中西医结合杂志,2017,27(3): |
| 整合素相互作用蛋白Kindlin家族与表皮干细胞增殖分化的相关性研究进展 |
| Research progress between integrin-interacting protein kindlin family and epidermal stem cell |
| 投稿时间：2016-05-11 修订日期：2016-07-15 |
| DOI： |
| 中文关键词: Kindlin家族 整合素 表皮干细胞 |
| 英文关键词:Kindlin family integrin epidermal stem cell |
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| 中文摘要: |
| 【】 表皮干细胞是皮肤组织特异性干细胞,在创伤修复、皮肤再造、基因治疗等方面都有很好的应用前景,其作用日益受到人们的重视。研究证明,表皮干细胞的增殖分化受其表面受体、各种调控因子、微环境等多因素的共同影响。Kindlin家族是一种新型的黏着斑蛋白,主要存在于表皮干细胞胞膜上,在细胞与细胞外基质黏附中起重要作用,通过有效活化整合素,实现对干细胞黏附、迁移和增殖等生理过程的调控。本文就表皮干细胞增殖分化中整合素相互作用蛋白Kindlin的作用机制进行综述。 |
| 英文摘要: |
| 【】 Epidermal stem cell is the specific stem cells of skin, which have a grate application prospect in wound healing, skin reconstruction, gene therapy and so on, attracted more and more attention. Studies have shown that, the proliferation and differentiation of epidermal stem cell aer influenced by receptors on their surface and various regulatory factors, micro environment, and many other factors.Kindlin family is a new type of vinculin, mainly exists on the epidermal stem cell membrane, which play an important role in the adhesion between cell and extracellular matrix (ECM),and achieve the regulation of stem cell adhesion, migration and proliferation by effectivity active the integrin. In this article, the mechanism of Kindlin during proliferation and differentiation of epidermal stem cell were reviewed. |
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