| 张慧和,黄建平.五子衍宗汤治疗帕金森轻度认知功能障碍(肾虚髓减型)的临床疗效评价[J].浙江中西医结合杂志,2016,26(11): |
| 五子衍宗汤治疗帕金森轻度认知功能障碍(肾虚髓减型)的临床疗效评价 |
| Clinical effect evaluation of five Zi Yan Zong Decoction(WYD) in treatment mild cognitive impairment in Parkinson's disease(kidney and marrow deficiency syndrome) |
| 投稿时间：2016-05-25 修订日期：2016-07-19 |
| DOI： |
| 中文关键词: 帕金森氏病 帕金森轻度认知功能障碍 五子衍宗汤 |
| 英文关键词:Parkinson's disease Mild cognitive impairment in Parkinson’s disease Wuzi Yanzong Decoction |
| 基金项目:浙江省自然科学基金项目 柔性纳米脂质体淫羊藿苷经鼻嗅区入脑治疗帕金森病的研究 LY14H280002 |
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| 中文摘要: |
| 目的 观察中药五子衍宗汤对帕金森轻度认知功能障碍(PD-MCI)(肾虚髓减型)的治疗作用。方法 将符合观察要求的50例PD-MCI患者分为治疗组(24例)和对照组(26例)。治疗组口服五子衍宗汤及盐酸多奈哌片,对照组口服盐酸多奈哌片,疗程12周,观察治疗前、治疗6周及治疗12周后的简明精神状态量表(MMSE)、蒙特利尔认知功能评估量表(MoCA)量表评分,中医症候评分的变化。结果 治疗后,两组治疗12周,MoCA量表、MMSE量表评分均明显升高,而中医症候评分明显降低,差异有统计学意义(P＜0.05)；但6周后,对照组MoCA量表、MMSE量表评分均升高,而中医症候评分降低,差异无统计学意义(p＞0.05),治疗组评分量表明显变化,差异有统计学意义(P＜0.05)；与对照组相比,治疗组12周后MoCA量表、MMSE量表评分明显高于对照组,差异有统计学意义(P＜0.05)；治疗6周及治疗12周后,中医症候评分明显低于对照组,差异有统计学意义(P＜0.05)。治疗组的治疗有效率为91.67%高于对照组73.08%,差异具有统计学意义(P<0.05)。 结论 五子衍宗汤治疗帕金森轻度认知功能障碍(肾虚髓减型)有着较好的临床效果。 |
| 英文摘要: |
| Objective：To investigate the effect of Wuzi Yanzong Decoction (WYD) in treating mild cognitive impairment in Parkinson's disease (PD-MCI)(kidney and marrow deficiency syndrome).
Method: According to the standard, 50 patients with mild cognitive impairment in Parkinson's disease(PD-MCI) were divided into experimental group(n=24) and control group (n=26) randomly. The experimental group: WYD plus Aricept; The control group: Aricept. The course of treatment was 12 weeks. Observed before treatment, treatment for 6 weeks and 12 weeks of treatment after the MMSE and MoCA score,TCM syndrome score changes.
Results: MMSE and MoCA scores were improved in both groups, while TCM syndrome score changes had decreased significantly at 12 weeks after treatment, especially in the treatment group; but after 6 weeks, the control group of MoCA scale and MMSE scale were increased, and the TCM symptom score decreased, no difference statistical significance (P > 0.05), the treatment group score significantly, the difference was statistically significant (P < 0.05); compared with the control group, the treatment group after 12 weeks of MoCA scale and MMSE scale were significantly higher than the control group, the difference was statistically significant (P < 0.05); 6 weeks of treatment and treatment after 12 weeks, TCM syndrome score was significantly lower than the control group, the difference was statistically significant (P < 0.05). The effective rate of the treatment group was 73.08% higher than that of the control group (91.67%), the difference was statistically significant (P<0.05).
Conclusion: This proved that the Five Zi Yan Zong Decoction showed remarkable clinical effectiveness in the treatment of mild cognitive impairment in Parkinson's disease |
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