| 孙淑云,张宜群,吴燕平.化瘀散结法对子宫内膜息肉术后雌孕激素受体和Ki-67的影响观察[J].浙江中西医结合杂志,2017,27(4): |
| 化瘀散结法对子宫内膜息肉术后雌孕激素受体和Ki-67的影响观察 |
| Observation on effects of dissipating stasis and dispersing method on female progesterone receptor and Ki-67 in patients with Transit Cooperative Research Program |
| 投稿时间：2016-07-14 修订日期：2016-09-06 |
| DOI： |
| 中文关键词: 化瘀散结法，子宫内膜息肉，ER，PR，Ki-67 |
| 英文关键词:dissipating stasis and dispersing method, endometrial polyp, ER,PR,Ki-67 |
| 基金项目:浙江省中医药科技计划项目（2015ZB101） |
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| 中文摘要: |
| 目的：观察宫腔镜子宫内膜息肉切除术(TCRP)术后应用中药化瘀散结法分期治疗对子宫内膜的雌激素受体(ER)、孕激素受体(PR)和增殖细胞相关抗原Ki-67表达的影响。方法：2015年6月-2016年6月在浙江中医药大学附属宁波市中医院住院行TCRP且术后病理诊断为子宫内膜息肉的患者147例，以随机单盲法分为三组，49例术后予中药化瘀散结法分期治疗（中药组），49例术后予妈富隆片周期性治疗（西药组），49例术后不予任何药物治疗（对照组），疗程为3个月，用免疫组化法检测ER、PR及Ki-67在子宫内膜的表达，比较三组在3个月前后ER、PR及Ki-67的变化情况。结果：①ER表达：治疗前后三组组内比较：差异无统计学意义（P>0.05），治疗后三组比较：差异无统计学意义（P>0.05）；②PR表达：治疗前后三组组内比较：中药组及西药组PR表达升高，有显著差异(P<0.01)；对照组差异无统计学意义（P>0.05）；治疗后三组比较：有显著差异(P<0.01)；两两比较：中药组PR表达升高最明显；③KI-67表达：治疗前后三组组内比较：中药组与西药组Ki-67表达明显下降，有显著差异(P<0.01)，对照组差异无统计学意义（P>0.05）；治疗后三组比较：有显著差异(P<0.01)；两两比较：中药组Ki-67表达下降最明显。结论：TCRP术后应用中药化瘀散结分期治疗可提升PR表达，抑制Ki-67表达，达到防治子宫内膜息肉复发的治疗效果，值得临床推广。 |
| 英文摘要: |
| ［Abstract］Objective: To investigate the effects of dissipating stasis and dispersing method combined with stage traditional Chinese medicine therapy in patients with transcervical resection of polyps (TCRP) on the expression of estrogen receptor(ER), progesterone receptor (PR) as well as antigen Ki-67 relative to proliferative cells by hysteroscopy. Method: During June of 2015 to June of 2016, single blind grouping method was applied to 147 patients in Zhejiang university of Chinese medicine affiliated hospital in ningbo city, who were randomly divided into 3 groups, with a group of 49 patients receiving the treatment of dissipating stasis and dispersing method combined with stage traditional Chinese medicine therapy (Chinese Medicine Group), another group of 49 with the periodicity treatment of orally taking marvelon tablets (Western Medicine Group) and the rest receiving no treatment (control group). The whole course of treatment lasted 3 months, after which the three groups were compared on the base of the ER, PR and Ki-67 expression in endometrium recorded by IHC. Result: (1) ER expression: Within three groups before and after treatment comparison: there was no statistically significant difference (P > 0.05), and compare three groups after treatment, there was no statistically significant difference (P > 0.05);(2) PR expression: Within three groups before and after treatment comparison: traditional Chinese medicine and western medicine group PR expression increases, there were significant differences (P < 0.01);There was no statistically significant difference in the control group (P > 0.05);Compare three groups after treatment, there were significant differences (P < 0.01);Pairwise comparison: Chinese traditional medicine group PR expression increased most obviously;(3) KI - 67 expression: Within three groups before and after treatment comparison: traditional Chinese medicine and western medicine group KI - 67 expression significantly decreased, there were significant differences (P < 0.01), there was no statistically significant difference in the control group (P > 0.05);Compare three groups after treatment, there were significant differences (P < 0.01);Pairwise comparison: Chinese traditional medicine group of Ki - 67 expression had the greatest reduction. Conclusion: With the application of stage traditional Chinese medicine therapy after TCRP, can improve PR expression, inhibit Ki - 67 expression. Thus, this therapy is worthy of promotion. |
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