| 徐昇.连续性床边血液净化治疗高脂血症性急性重症胰腺炎的疗效观察[J].浙江中西医结合杂志,2017,27(4): |
| 连续性床边血液净化治疗高脂血症性急性重症胰腺炎的疗效观察 |
| Therapeutic effect of CRRT in treatment of patients with hyperlipidemic severe acute pancreatitis |
| 投稿时间：2016-07-21 修订日期：2016-11-08 |
| DOI： |
| 中文关键词: 连续性床边血液净化 高脂血症 急性重症胰腺炎 |
| 英文关键词:Continuous bedside blood purification Hyperlipidemia Acute severe pancreatitis |
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| 中文摘要: |
| 目的 探讨连续性床边血液净化(CRRT)对高脂血症性急性重症胰腺炎(HL-SAP)的治疗效果。方法 将29例患者随机分成治疗组和对照组,治疗组15例,对照组14例,观察两组患者分别在治疗24h、48h、72h后APACHEII评分、甘油三酯、平均动脉压(MAP)、乳酸、血肌酐、降钙素原(PCT)、C-反应蛋白等指标变化以及临床症状改善情况(主要观察指标为腹痛评分)。结果 治疗组15例患者经CRRT治疗后临床症状有不同程度改善；对照组有3例患者病情加重,其中2例并发急性肾功能衰竭,1例并发肺水肿,氧合指数下降行机械通气。治疗24h、48h、72h后两组患者在APACHEII评分、甘油三酯、平均动脉压(MAP)、乳酸、血钙、血肌酐、降钙素原(PCT)、C-反应蛋白等指标变化上有显著差异(p＜0.05),有统计学意义。治疗过程中未出现出血、栓塞、心脑血管意外等严重并发症。结论 CRRT可以有效清除急性重症胰腺炎所产生的一系列炎性因子,降低甘油三酯,改善患者临床症状,是治疗高脂血症性急性重症胰腺炎的有效方法之一。 |
| 英文摘要: |
| Objective: To investigate the effect of CRRT on the treatment of patients with hyperlipidemic severe acute pancreatitis. Methods: 29 cases of patients were randomly divided into treatment group and control group, treatment group(n = 15), control group (n = 14). After 24h, 48h, 72h, To observe the two groups of patients in APACHE II score, triglyceride (TG), mean arterial pressure (map), lactic acid, serum creatinine (SCR), calcitonin angiotensinogen (PCT), C-reactive protein and other indicators of changes and clinical symptoms improvement (main outcome measures for abdominal pain score).Results: The clinical symptoms of 15 patients in the treatment group were improved in different degree. In the control group, 3 cases of patients with exacerbations, which 2 cases were complicated with acute renal failure, 1 case was complicated with pulmonary edema, oxygenation index decreased mechanical ventilation. After 24h, 48h, 72h, two groups of patients in the APACHE II score, triglyceride (TG), mean arterial pressure (map), lactic acid, calcium, serum creatinine (SCR), calcitonin angiotensinogen (PCT), C-reactive protein and other indexes have significant difference (P<0.05) and was statistically significant. And there were no serious complications such as bleeding, embolism, cardiac and cerebral vascular accident in the course of treatment. Conclusions: CRRT can effectively remove the severe acute pancreatitis (SAP) produced a series of inflammatory cytokines and reduce triglycerides, improve the clinical symptoms of the patients, the treatment of hyperlipidemic severe acute pancreatitis (SAP) is one of the effective methods. |
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