| 臧敏,陈秀华,林文波,蔡岗丽,周明镜,刘超群.中医外治法对慢性阻塞性肺疾病的症状影响及免疫机制的研究[J].浙江中西医结合杂志,2016,26(11): |
| 中医外治法对慢性阻塞性肺疾病的症状影响及免疫机制的研究 |
| Variation of clinical symptoms caused by external therapy of chinese medicine to patients with chronic obstructive pulmonary disease(COPD) in stable periodand and the study of its immunity mechanism |
| 投稿时间：2016-07-22 修订日期：2016-08-10 |
| DOI： |
| 中文关键词: 中医外治法 针灸 贴敷 慢性阻塞性肺疾病 免疫机制 |
| 英文关键词:external therapy of Chinese medicine acupuncture and moxibustion therapy acupoint application therapy chronic obstructive pulmonary disease(COPD) immunity mechanism |
| 基金项目:金华市科技局社发类重点项目 2014-3-017 |
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| 中文摘要: |
| 目的：观察针灸及贴敷外治法对于慢性阻塞性肺疾病稳定期患者的临床症状、T淋巴细胞亚群CD3、CD4、CD8以及血清免疫球蛋白IgM、 IgA 、IgG的影响,探讨针灸及贴敷外治法治疗本病的可能作用机制。方法：92例患者被随机分为3组。对照组36例,予舒利迭联合噻托溴铵吸入治疗；观察1组24例,在对照组方案基础上加用穴位贴敷治疗,10天为一疗程,每月1疗程,共治疗6个月；观察2组32例,在对照组方案基础上加用针灸联合穴位贴敷治疗,10天为一疗程,每月1疗程。共治疗6个月。比较每组治疗前后中医证候积分、CAT量表评分及CD3、CD4、CD8、IgM、 IgA 、IgG的变化情况。结果：中医证候积分比较：对照组治疗前后差异无统计学意义(p>0.05),观察1组治疗前后比较,差异具有统计学意义(p<0.05)；观察2组治疗前后比较,差异具有显著统计学意义(p<0.01)。治疗后三组比较,差异具有统计学意义(p<0.01)；观察1、2组治疗后比较,差异无统计学意义(p>0.05)。CAT评分比较：对照组治疗前后差异无统计学意义(p>0.05)；观察1组治疗前后差异无统计学意义(p>0.05)；观察2组治疗前后比较,差异具有统计学意义(p<0.01)；治疗后三组比较,差异具有统计学意义(p<0.01)。T淋巴细胞亚群分布比较：对照组治疗前后CD3、CD4、CD8水平比较,差异均无统计学意义(p>0.05)。观察1组、观察2组的治疗前后CD3、CD4水平比较,差异具有统计学意义(p<0.05)；CD8、CD4/CD8水平比较,差异无统计学意义(p>0.05)。治疗后三组比较CD3、CD4水平比较,差异具有显著统计学意义(p<0.01)；CD8、CD4/CD8水平比较,差异无统计学意义(p>0.05)。血清免疫球蛋白含量比较：对照组治疗前后IgM、IgA、IgG水平比较,差异均无统计学意义(p>0.05)。观察1组、观察2组的治疗前后IgG水平比较,差异具有统计学意义(p<0.05)；IgM、IgA水平比较,差异无统计学意义(p>0.05)。结论：中医外治法的贴敷治疗或贴敷联合针灸治疗能改善慢阻肺稳定期临床症状,且联合治疗在改善CAT评分方面具有优势。该外治法可能通过提高T淋巴细胞CD3、CD4及血清IgG水平来调节机体免疫功能,从而改善疾病临床症状。 |
| 英文摘要: |
| Objective:To observe the variation of clinical symptoms and immunity function by external therapy of Chinese medicine to patients with chronic obstructive pulmonary disease(COPD) in stable period.Methods: 92 patients were randomly divided into three groups,control group(n=36),research 1 group(n=24),and research 2 group(n=32).Conventional inhalation therapy were provided in three groups,combined with acupoint application therapy in research 1 group ,and combined with acupoint application added with acupuncture and moxibustion therapy in research 2 group. The variation of clinical symptoms and immunity function were compared. Results：The variation of clinical symptoms based on TCM symptom score and on CAT scale in two research groups are better than in control group(p<0.05). The level of T-lymphocyte subsets CD3、CD4 are both improved in two research groups after treatments(p<0.05). The level of serum immunology IgG are both improved in two research groups after treatments(p<0.05). No obvious difference to improve the level of serum immunology IgM and IgA among three groups(p>0.05). Conclusion:External therapy of chinese medicine to patients with COPD in stable period is efficient. It can improve the clinical symptoms, improve he level of T-lymphocyte subsets CD3、CD4 and the level of serum immunology IgG. |
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