| 金青.奥拉西坦联合胆碱酯酶抑制剂对脑梗死后认知功能障碍患者效果观察及对患者日常生活能力的影响[J].浙江中西医结合杂志,2017,27(2): |
| 奥拉西坦联合胆碱酯酶抑制剂对脑梗死后认知功能障碍患者效果观察及对患者日常生活能力的影响 |
| Oxiracetam joint cholinesterase inhibitors on cognitive dysfunction after cerebral infarction efficacy and impact on patients |
| 投稿时间：2016-07-30 修订日期：2016-12-09 |
| DOI： |
| 中文关键词: 奥拉西坦 胆碱酯酶抑制剂 脑梗死 认知功能障碍 效果 日常生活能力 |
| 英文关键词:Oxiracetam cholinesterase inhibitors cerebral infarction cognitive dysfunction effects daily living |
| 基金项目: |
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| 中文摘要: |
| 目的：探讨奥拉西坦联合胆碱酯酶抑制剂对脑梗死后认知功能障碍患者效果观察及对患者日常生活能力的影响。方法：选自我院于2014年3月~2016年3月期间收治的脑梗死后认知功能障碍患者74例,依据随机数字表法随机分为观察组37例与对照组37例。对照组给予胆碱酯酶抑制剂多奈哌齐治疗,观察组在对照组基础上结合奥拉西坦注射液治疗。两组疗程均为4周。比较两组患者认知功能、日常生活能力改善情况及不良反应发生情况。结果：两组MMSE评分治疗后增加(P<0.05)；观察组MMSE评分高于对照组(P<0.05)；两组MoCA评分治疗后增加(P<0.05)；观察组MoCA评分高于对照组(P<0.05)；两组BI指数评分治疗后增加(P<0.05)；观察组BI指数评分高于对照组(P<0.05)；观察组治疗总有效率(78.38%)高于对照组(56.76%)(P<0.05)；两组心电图、血常规、尿常规、肝肾功能未见异常,且无明显药物不良反应。结论：奥拉西坦联合胆碱酯酶抑制剂对脑梗死后认知功能障碍患者效果显著,可明显改善患者认知功能和日常生活能力,且安全性良好,值得研究。 |
| 英文摘要: |
| Objective: To investigate oxiracetam joint cholinesterase inhibitors on cognitive dysfunction after cerebral infarction efficacy and impact on patients" daily living. Method: Selected hospital in March 2014 - March 2016 period infarction treated 74 patients with cognitive dysfunction, were randomly divided into observation group 37 cases and control group 37 cases. The control group received cholinesterase inhibitor donepezil treatment, combined with the observation group oxiracetam injection treatment in the control group basis. The treatment lasted 4 weeks. Were compared cognitive function, activities of daily living to improve the situation and adverse events. Results: Two groups MMSE score after treatment increased (P<0.05); the observation group MMSE score were higher than control group (P<0.05); two groups after treatment MoCA scores increased (P<0.05); the observation group MoCA score were higher than control group (P<0.05); after treatment the two groups BI index score increased (P<0.05); the observation group BI index score was higher control group (P<0.05); the observation group total effective rate (78.38%) was higher control group (56.76%) (P<0.05); two groups electrocardiogram, blood, urine, liver and kidney functions were normal, and no significant adverse drug reactions. Conclusion: oxiracetam joint cholinesterase inhibitors on cognitive dysfunction after cerebral infarction significant effect, can significantly improve patients" cognitive function and activities of daily living, and the security is good, is worth studying. |
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