| 刘恺远,牟新,马静茹,詹魁骏.维生素D治疗肺结核疗效的系统评价[J].浙江中西医结合杂志,2017,27(4): |
| 维生素D治疗肺结核疗效的系统评价 |
|
| 投稿时间：2016-08-17 修订日期：2016-09-20 |
| DOI： |
| 中文关键词: 维生素D 肺结核 系统评价 |
| 英文关键词:Tuberculosis Vitamin D Systematic Review |
| 基金项目: |
|
| 摘要点击次数: 1171 |
| 全文下载次数: 8 |
| 中文摘要: |
| 目的：系统评价维生素D辅助治疗肺结核的疗效。 方法：计算机检索Cochrane Library、PubMed、EMbase、CBM、VIP、CNKI数据库，检索文献发表时间为2000年至2016年5月。由2名研究者按照纳入与排除标准独立筛选文献、提取资料并采用Jadad量表对纳入的随机对照试验（RCT）进行质量评价后，用RevMan 5.3 软件进行Meta 分析。 结果：最终纳入4个随机对照试验，合计790例患者。荟萃分析结果显示：结果显示维生素D组与对照组相比在4周痰涂片或痰培养阴转率上差异无统计学意义P=0.30（P＞0.05）。 结论：基于此次Meta分析维生素D不能加快肺结核治疗的进程。对于维生素D在肺结核中应用的价值可能在于预防大于治疗，仍需包含更多月份痰阴转率的RCT研究以提供更充分可靠的证据。 |
| 英文摘要: |
| Abstract OBJECTIVE: To evaluate the efficacy of vitamin D as a adjuvant treatment of tuberculosis. Methods: We searched the Cochrane Library, PubMed, EMbase, CBM, VIP, CNKI database, retrieve Published literature from 2000 to May 2016, After the two investigators according to inclusion and exclusion criteria independently screened the literature, extracted data and using the Jadad scale evaluated the quality of the included randomized controlled trials (RCT), analyzed using Rev Man 5.3 software. Results: The final included four randomized controlled trials, a total of 790 cases of patients. Meta-analysis showed: The results showed that four weeks sputum smear or culture conversion rate of the vitamin D group compared with the placebo group showed no significant difference P = 0.30 (P> 0.05). Conclusion: Based on the Meta-analysis vitamin D can not speed up the process of tuberculosis treatment. The value of vitamin D application in tuberculosis may lie in the preventive greater than treatment, still more RCT study contains more month sputum conversion rate to provide a more adequate and reliable evidence. |
| 查看全文 查看/发表评论 下载PDF阅读器 |
| 关闭 |
|
|
|
