| 张忠良,林俊宏.自体富血小板血浆关节腔内注射治疗膝骨性关节炎的疗效观察[J].浙江中西医结合杂志,2017,27(11): |
| 自体富血小板血浆关节腔内注射治疗膝骨性关节炎的疗效观察 |
| Effects observation of intra-articular injection with autologous platelet-rich plasma on knee osteoarthritis |
| 投稿时间：2016-12-04 修订日期：2017-09-04 |
| DOI： |
| 中文关键词: 自体富血小板血浆关节腔内注射治疗 膝骨性关节炎的疗效观察 |
| 英文关键词:Osteoarthritis, Knee Platelet-rich plasma Hyaluronic acid |
| 基金项目:金华市科技计划项目2014-3-081 |
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| 中文摘要: |
| 【】 目的 探讨自体富血小板血浆(PRP,Platelet-richSplasma)相比较透明质酸(HA,Hyaluronic acid)钠关节腔内注射治疗轻中度膝骨性关节炎的临床疗效。方法 选择2014年8月至2016年2月金华市中医医院收治的膝骨性关节炎II、III级病人52例,进行随机分组,观察组(PRP)26例26膝,对照组(HA)26例26膝,观察组采用4ml PRP关节腔注射治疗(共3次一疗程),对照组采用2ml HA注射治疗(共5次一疗程)。两组患者在治疗前及治疗结束后1、3、6个月分别用视觉模拟疼痛评分(VAS评分)及Western Ontario与McMaster大学骨关节炎指数评分(WOMAC评分)进行评分。结果 观察组24例、对照组23例获得了6个月以上的随访,两组在性别、年龄、膝骨关节炎分级、治疗前VAS评分、WOMAC评分上差异均无统计学意义(P＞0.05)。观察组及对照组治疗后VAS评分及WOMAC评分较治疗前均得到显著改善(P＜0.05)；观察组治疗后1、3、6个月间VAS评分及WOMAC评分无统计学差异(P＞0.05),对照组治疗后6个月VAS评分及WOMAC评分高于治疗后1、3个月(P＜0.05)；两组治疗后1、3个月,VAS评分及WOMAC评分差异无统计学差异(P＞0.05),而治疗后6个月观察组各指标优于对照组,差异有统计学意义(P＜0.05)。结论 PRP关节腔内注射治疗可显著缓解轻中度膝骨性关节炎患者的疼痛及改善关节功能,较HA钠疗效更持久。 |
| 英文摘要: |
| Objective To discuss the clinical effects of intra-articular injection with platelet-rich plasma on knee osteoarthritis compared to hyaluronic acid. Methods A total of 52 patients belonged to grade II and III knee osteoarthritis in Jinhua Hospital of TCM from August 2014 to February 2016 were selected, and devided into two groups randomly, observation group (PRP) and control group (HA) (26 cases each). Observation group accepted intra-articular injection of 4ml PRP three times a cycle, while control group accepted injection of 2ml HA five times a cycle. And they were all evaluated before treatment and at 1,3 and 6 months after treatment by visual analogue scale score (VAS) and Western Ontario and McMaster Universities Osteoarthritis Index score ( WOMAC). Results 24 patients in Observation group and 23 patients in control group were followed up for at least 6 months. There had no statistically significant differences on gender, age, degree of knee osteoarthritis, WOMAC scores and VAS scores between the two groups（P＞0.05）. Between pre- and post-treatment, the WOMAC scores and VAS scores had significant differences in both groups（P＜0.05）. 1, 3 and 6 months after treatment in observation group, there were no significant difference on WOMAC scores and VAS scores between groups（P＞0.05）, but 6 months after treatment in control group were higher than 1 and 3 months after treatment（P＜0.05）. The differences were not statistically significant on WOMAC scores and VAS scores at 1 and 3 months after treatment between the two groups（P＞0.05）, but statistically significant at 6 months after treatment（P＜0.05）. Conclusion Intra-articular injection with platelet-rich plasma can significantly relieve the pain and improve the function in patients with knee osteoarthritis, and the curative effects are more lasting than HA. |
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