| 应漂.甲钴胺注射液治疗维持性血液透析患者不安腿综合征疗效及对睡眠质量的影响[J].浙江中西医结合杂志,2017,27(11): |
| 甲钴胺注射液治疗维持性血液透析患者不安腿综合征疗效及对睡眠质量的影响 |
| The curative effect of mecobalamin injection on restless leg syndrome in maintenance hemodialysis patients and its effect on sleep quality |
| 投稿时间：2017-03-24 修订日期：2017-06-05 |
| DOI： |
| 中文关键词: 甲钴胺注射液 血液透析 不安腿综合征 临床疗效 生活质量 睡眠质量 |
| 英文关键词:Methylcobalamin injection Hemodialysis Restless leg syndrome Clinical efficacy Sleep quality |
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| 中文摘要: |
| 目的 探讨甲钴胺注射液治疗维持性血液透析患者不安腿综合征(RLS)临床疗效,并评估对患者临床症状和睡眠质量的改善作用。方法 选择本院2015年3月至2016年12月RLS患者98例,随机分为对照组和研究组,两组各49例。对照组给予美多芭治疗,研究组在给予美多芭治疗基础上应用甲钴胺治疗。观察两组患者临床疗效、采用国际RLS 标准(IRLS)评分评估治疗前后症状改善作用,并评估睡眠质量。结果 研究组总有效率为91.84%(45/49),高于对照组75.51%(37/49),差异有统计学意义(P＜0.05),研究组治疗后IRLS评分为(8.10±2.27)分,低于对照组治疗后(9.85±2.19)分,差异有统计学意义(P＜0.05)；研究组治疗后PSQI总分为(6.04±1.16)分,低于对照组治疗后(7.28±1.32)分,差异有统计学意义(P＜0.05)。结论 甲钴胺注射液治疗维持性血液透析患者RLS临床疗效显著,患者临床症状和睡眠质量均得到显著改善。 |
| 英文摘要: |
| Objective To explore the clinical efficacy of mecobalamin injection for the treatment of maintenance hemodialysis patients with restless leg syndrome (RLS) and to evaluate the improvement of clinical symptoms and sleep quality. Methods 98 patients with RLS from March in 2015 to December in 2016 were selected and randomly divided into control group and study group. The control group was given methadonna treatment and the study group was treated with methicylamine on the basis of methadopa treatment. To observe the clinical efficacy of two groups, assessed the role of symptoms using the international RLS standard (IRLS) score before and after treatment, and assessed the quality of sleep. Results The total effective rate of the study group was 91.84% (45/49), which was significantly higher than that of the control group 75.51%(37/49), the difference was statistically significant (P <0.05).The IRLS score of the study group was (8.10±2.27)points, which was lower than that in the control group (9.85±2.19) points, the difference was statistically significant (P<0.05). The total score of PSQI of the study group was (6.04±1.16) points,which was lower than that of the control group (7.28±1.32), the difference was statistically significant (P<0.05).Conclusion It has the better clinical treatment effective of Methylcobalamin injection for maintenance hemodialysis patients with RLS。The clinical symptoms and sleep quality of patients were significantly improved. |
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