| 严可风,何月利.益气活血化瘀汤辅助BiPAP治疗AECOPD并呼吸衰竭的临床疗效观察[J].浙江中西医结合杂志,2017,27(11): |
| 益气活血化瘀汤辅助BiPAP治疗AECOPD并呼吸衰竭的临床疗效观察 |
| Clinical observation of Yiqihuoxuehuayu decoction combined with BIPAP in the treatment of AECOPD with respiratory failure |
| 投稿时间：2017-04-13 修订日期：2017-09-12 |
| DOI： |
| 中文关键词: 益气活血化瘀汤 BiPAP AECOPD 呼吸衰竭 |
| 英文关键词:Yiqihuoxuehuayu Decoction BiPAP AECOPD Respiratory failure |
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| 中文摘要: |
| 目的：探讨益气活血化瘀汤辅助双水平式呼吸道正压通气(BiPAP)治疗慢性阻塞性肺疾病急性加重期(AECOPD)并呼吸衰竭的临床疗效观察。方法：将72例AECOPD并呼吸衰竭患者分为观察组和对照组。全部患者给予常规对症治疗。对照组采用BiPAP治疗。观察组在对照组基础上,给予益气活血化瘀汤。对比两组治疗前后血气水平、肺功能、炎症因子的水平变化。结果：观察组的治疗效果较对照组更佳,差异有统计学意义(P<0.05)；两组治疗后的PH值、血氧分压(PaO2)、氧合指数(P/F)明显升高,血二氧化碳分压(PaCO2)明显降低(P<0.05)；治疗后,观察组的PaO2、P/F明显高于对照组,PaCO2明显低于对照组,差异有统计学意义(P<0.05)；两组治疗后超敏C反应蛋白(hs-CRP)、白介素8(IL-8)、白介素1β(IL-1β)较治疗前均明显降低(P<0.05)；治疗后,观察组的hs-CRP、IL-8、IL-1β显著优于对照组,差异有统计学意义(P<0.05)；两组治疗后一秒用力呼气容积(FEV1)、FEV1/FVC、呼气峰值流速(PEF)明显升高(P<0.05)；治疗后,观察组的FEV1、FEV1/FVC、PEF明显高于对照组,差异有统计学意义(P<0.05)。结论：益气活血化瘀汤辅助BiPAP治疗AECOPD并呼吸衰竭,能有效提高治疗效果。 |
| 英文摘要: |
| Objective: To investigate the clinical effect of Yiqihuoxuehuayu decoction combined with BIPAP in the treatment of AECOPD with respiratory failure. Methods: 72 patients with AECOPD and respiratory failure were divided into observation group and control group. All patients were given conventional symptomatic treatment. The control group was treated with BIPAP. The observation group was given Yiqihuoxuehuayu Decoction on the basis of the control group. The changes of blood gas, lung function and inflammatory factors were compared between the two groups before and after treatment. Results: the treatment effect of the observation group was better than that of the control group. The difference was statistically significant (P<0.05). After treatment, the pH value, PaO2 and OI of the two groups were significantly increased, PaCO2 was significantly lower (P<0.05). After treatment, the PaO2 and OI in the observation group were significantly higher than those in the control group, PaCO2 was significantly lower than that in the control group. The difference was statistically significant (P<0.05). After treatment, the hs-CRP, IL-8 and IL-1β of the two groups were significantly lower than those before treatment (P<0.05). After treatment, hs-CRP, IL-8 and IL-1β in the observation group were significantly better than those in the control group. The difference was statistically significant (P<0.05). FEV1, FEV1/FVC and PEF were significantly increased after treatment in the two groups (P<0.05). After treatment, the FEV1, FEV1/FVC and PEF in the observation group were significantly higher than those in the control group. The difference was statistically significant (P<0.05). Conclusion: the treatment of BIPAP combined with Yiqihuoxuehuayu in the treatment of AECOPD with respiratory failure can effectively improve the therapeutic effect. |
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