| 陈艳,陈少芬,陈思思,郑永克.高龄糖尿病患者肾功能及相关危险因素分析[J].浙江中西医结合杂志,2018,28(2): |
| 高龄糖尿病患者肾功能及相关危险因素分析 |
| The kidney function of the elderly type 2 diabetic patients and associated risk factors |
| 投稿时间：2017-05-23 修订日期：2018-01-18 |
| DOI： |
| 中文关键词: 糖尿病，2型 肾功能不全 肾小球滤过率 危险因素 |
| 英文关键词:Diabetes mellitus,type 2 Renal insufficiency Glomerular filtration rate Risk factors |
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| 中文摘要: |
| 目的:了解高龄糖尿病老年人肾功能的情况及相关危险因素。 方法: 选择本院≥80岁老年糖尿病住院患者270例，同时选择来我院健康体检的≥80岁的非糖尿病老人100例为对照组，通过测定血FBG、BUN、Scr、SUA、Hcy、HbA1c等，用CKD-EPI公式估算肾小球滤过率(eGFR)值。 结果: 270例糖尿病患者中，eGFR平均值为(53.83±24.86）ml?min-1?1.73 m-2,肾功能下降的发生率为55.9%。肾功能下降组与肾功能正常组比较，BUN、Scr、SUA、Hcy、ACR异常率均偏高，但HBA1c偏低(P<0.05)。Spearman相关分析结果显示，eGFR与SBP、BUN、Scr、SUA、TC、Hcy呈负相关，与FPG、HbA1c呈正相关(P＜0.05)。排除年龄、性别、BMI的影响，多因素Logistic回归分析显示，病程、收缩压、尿素氮、高尿酸血症、高胆固醇血症是肾功能下降的危险因素（OR=2.671、2.707、5.078、4.188、3.422，均P<0.05），舒张压升高是保护因素（OR=0.033，P<0.01）。 结论:高龄糖尿病老年人肾功能异常率高，影响其风险因素较多。 |
| 英文摘要: |
| Objective: To investigate the kidney function of the elderly type 2 diabetic patients and associated risk factors. Methods: Hospitalized type 2 diabetic patients aged ≥80 years of our hospital (n=270) were tested for morning serum creatinine,serum urea,serum uric acid,urinate.CKD-EPI equation estimated GFR assessed renal function. Results : The average value of eGFR was (53.83±24.86) ml?min-1?1.73 m-2，and the proportion of patients with low eGFR(＜60 ml?min-1?1.73 m-2) 55.9% . Decline in renal function group and normal renal function group, BUN, Scr, SUA, ACR abnormal rate, Hcy were increased, but HBA1c lower (P <0.05).Spearman correlation analysis showd eGFR was negatively correlated with SBP，BUN，Scr，SUA，TG，Hcy，and was positively correlated with FBG,HbA1c(P<0.05).Excluding the effects of age，sex，BMI's，longer diabetic duration, SBP, BUN, HUA ,TC were independently associated with decline in renal function(OR=2.671,2.707,5.078,4.188,3.422,respectively，all P﹤0.05）, and DBP was a protective factor(P<0.01).Conclusions: Senile renal dysfunction rate in elderly type 2 diabetic patients , many factors affect the risk. |
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