| 周彬.腹腔镜下胆囊切除术对体液免疫的影响研究[J].浙江中西医结合杂志,2018,28(1): |
| 腹腔镜下胆囊切除术对体液免疫的影响研究 |
| Effects of laparoscopic cholecystectomy on humoral immune function |
| 投稿时间：2017-06-14 修订日期：2017-06-28 |
| DOI： |
| 中文关键词: 腹腔镜 胆囊切除术 免疫功能 应激 |
| 英文关键词:laparoscopic cholecystectomy immune function stress |
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| 中文摘要: |
| 目的探讨腹腔镜下胆囊切除术 对机体体液免疫功能及应激水平的影响。方法于2012年6月至2016年5月，在我院随机选取158例行腹腔镜下胆囊切除术的急性结石性胆囊炎患者为实验组，再选择同期进行传统开腹胆囊切除术的急性结石性胆囊炎患者158例为对照组。观察手术前及手术三天后患者C反应蛋白、白介素-6、肿瘤坏死因子-α、CD3与CD4 的变化情况。结果：手术前，实验组和对照组患者的免疫指标和应激指标差异均无统计学意义（P >0.05)；手术三天后，实验组患者的C反应蛋白、白介素-6和肿瘤坏死因子-α水平均显著低于对照组，而CD3与 CD4 值明显高于对照组，差异具有统计学意义(P<0.05)。结论腹腔镜下胆囊切除术对患者机体体液免疫功能及应激的保护优于传统开腹胆囊切除术，更有利于术后恢复。 |
| 英文摘要: |
| Objective To observe the effect of laparoscopic cholecystectomy on the body’s stress and humoral immune function. Methods From June 2012 to May 2016, 158 patients with acute calculouscholecystitis undergoing laparoscopic cholecystectomy were randomly selected as the experimental group.158 patients with acute calculouscholecystitis undergoing traditional open cholecystectomy were randomly selected as the control group in our hospital meantime. The C-reactive protein，Interleukin-6，tumor necrosis factor-α，CD3 and CD4 were observed before operation and 3 days after surgery. Results There were no significant difference in immune response and stress indicators between the two groups(P<0.05)．Compared with control group post-treatment,the C-reactive protein，Interleukin-6 and tumor necrosis factor-αwere significantly lower in the experimental group 3 days after surgery(P<0.05).The CD3 and CD4 were significantly higher in the experimental group ,there difference was significant(P<0.05).Conclusion Laparoscopic cholecystectomy surgery is superior to conventional open cholecystectomy surgery in stress protection，the protection of immune function and postoperative recovery. |
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