| 许冈跃,浦春宁.rh-aFGF与rh-bFGF治疗Ⅱ度烧伤患者的疗效及炎症因子的观察对比[J].浙江中西医结合杂志,2018,28(7): |
| rh-aFGF与rh-bFGF治疗Ⅱ度烧伤患者的疗效及炎症因子的观察对比 |
| Rh - aFGF Ⅱ degree burns patients treated with rh - bFGF observation of curative effect and inflammatory factor comparison |
| 投稿时间：2017-09-15 修订日期：2018-06-15 |
| DOI： |
| 中文关键词: 重组人酸性成纤维细胞生长因子 重组人碱性成纤维细胞生长因子 烧伤 炎症因子 |
| 英文关键词:recombinant human acidic fibroblast growth factor, rh-aFGF recombinant human basic fibroblast growth factor, rh-bFGF empyrosis inflammatory factors |
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| 中文摘要: |
| 【摘要】目的：探讨rh-aFGF与rh-bFGF治疗Ⅱ度烧伤患者的疗效及炎症因子的观察对比
。方法：以54名四肢深Ⅱ度烧伤患者作为研究对象，应用rh-aFGF以及rh-bFGF治疗四肢深Ⅱ度烧伤创面，统计创面愈合百分率、创面愈合时间、疤痕增生情况、全身恢复情况、不良反应发生情况、炎症情况等指标。结果：手术治疗后1周、2周两组创面愈合百分率具有显著统计学差异（P＜0.001），手术后3周实验组与对照组比较差异具有统计学差异（P＜0.05）。实验组，对照组平均愈合天数具有统计学意义（P＜0.05）。两组患者疤痕评分及疤痕高度、疤痕面积具有显著统计学差异。患者创面渗出物白细胞数量无显著统计学差异（P＞0.05）。手术后1周实验组与对照组患者创口渗出液中TNF-α、IL-1浓度均有统计学差异，2周、3周均无统计学差异。不良反应及全身恢复情况方面两组未见显著差异。结论：rh-aFGF治疗烧伤患者的疗效优于rh-bFGF，有效减轻炎症反应，无明显不良反应。 |
| 英文摘要: |
| 【】Objective: To determine the effect of recombinant humanfibroblast factor。Methods: 54 limb wounds deep second degree burn patients were included. Results: 1week, 2 weeks, 3 weeks after operation, wound healing in test group were significantly better than the control group. The average healing days of the two groups was statistically significant (P < 0.05). There were significant differences in scar score and scar height between the two groups, and the scar area was statistically significant. The wound exudate was taken at 1, 2 and 3 weeks after the end of the operation, and the WBC count was not statistically significant (P > 0.05). 1 weeks after operation, the concentrations of TNF-α, IL-1 in the exudate were statistically different. There was no significant difference in adverse reactions and general recovery between the two groups. Conclusion: rh-aFGF is better than rh-bFGF in the treatment of burn patients. |
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