| 盛云飞,崔恒,章先锋,朱晓玉.儿童颅内非典型畸胎瘤/横纹肌样瘤MRI影像表现[J].浙江中西医结合杂志,2018,28(4): |
| 儿童颅内非典型畸胎瘤/横纹肌样瘤MRI影像表现 |
| MRI Feature Of Pediatric Central Nervous System Atypical Teratoid–Rhabdoid Tumor |
| 投稿时间：2017-10-22 修订日期：2018-02-21 |
| DOI： |
| 中文关键词: 非典型畸胎瘤/横纹肌样瘤 磁共振成像 儿童 |
| 英文关键词:atypical teratoid–rhabdoid tumor MRI children |
| 基金项目: |
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| 中文摘要: |
| 目的 通过比较儿童中枢神经系统非典型畸胎瘤/横纹肌样瘤和髓母细胞瘤的影像学表现，探索其与髓母细胞瘤不同的特征性影像表现。方法 回顾性分析经病理证实的69例患者（52髓母细胞瘤和17非典型畸胎瘤样横纹肌样瘤）的临床和影像资料，比较两组的临床和影像学特点。结果 非典型畸胎瘤样横纹肌样瘤发病年龄3.00±2.57 岁(0.5–9岁)低于髓母细胞瘤4.75±2.52 岁(0.33–9.75岁) (p=0.0098)。研究组男孩13例，女孩4例；对照组男孩37例，15例女孩，两组肿瘤男女发病率无差异。9例（52.9%）非典型畸胎瘤样横纹肌样瘤位于幕下，所有髓母细胞瘤均位于幕下。10例（58.8%）非典型畸胎瘤样横纹肌样瘤和4例（7.69%）对照组发生在偏中线部位(p<0.0001)。肿瘤内出血在研究组中12例（70.59%），发生率明显高于对照组(2/52，3.85%) (p<0.0001)。肿瘤周围囊变在非典型畸胎瘤样横纹肌样瘤出现（11/17，64.71%）高于髓母细胞瘤（34.62%）(p=0.0291)。软脑膜播散和周围水肿在两者之间差异无统计学意义。
结论 非典型畸胎瘤样横纹肌样瘤和髓母细胞瘤的影像学特征相似，发病年龄小、偏离中线部位、肿瘤内出血和边缘囊变特征更常见于非典型畸胎样瘤横纹肌样瘤，肿瘤内出现和边缘囊变具有鉴别诊断意义。 |
| 英文摘要: |
| OBJECTIVE: The goal of our study was to find the distinguishing imaging characteristics to be differentiated atypical teratoid–rhabdoid tumor from medulloblastoma in preoperative diagnosis.
MATERIALS AND METHODS: Preoperative MRI examinations of 69 patients (52 medulloblastomas and 17 atypical teratoid–rhabdoid tumors) were analyzed retrospectively. Imaging characteristics of atypical teratoid–rhabdoid tumor and medulloblastoma were assessed with conventional MRI.
RESULTS: There were 13 males and 4 females in atypical teratoid–rhabdoid tumor, while 37 males and 15 females in medulloblastoma ( p=0.7633)The mean ages of patients with atypical teratoid–rhabdoid tumor and medulloblastoma were 3.00±2.57 years(age range, 0.5–9years)and 4.75±2.52 years (age range, 0.33–9.75years,respectively(p=0.0098). Ten（58.82%) atypical teratoid rhadoid tumors occurred at eccentric midline,4 (7.69%)medulloblastomas presented eccentric midline.(p＜0.0001). Nine(52.9%) atypical teratoid rhabdoid tumors were infratentorial area and all medulloblastomas were infratentorial. Intratumoral hemorrhage was dominant in twelve atypical teratoid–rhabdoid tumors (70.59%)and in two medulloblastomas (3.85%) (p<0.0001). The peripheral cystic components were more common in 11 atypical teratoid–rhabdoid tumors (11/17,64.71%) than in medulloblastoma(18/52,34.62%)(p=0.0291).The peritumoral edema and cerebrospinal fluid dissemination were not significantly different between the two tumors.
CONCLUSION: Atypical teratoid–rhabdoid tumor presents at a younger age than medulloblastoma. Peripheral cystic components and intratumoral hemorrhage are more common in atypical teratoid–rhabdoid tumor, which could be useful as differential features of atypical teratoid–rhabdoid compared with medulloblastomas. |
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