| 龚黎燕,周琴飞,鲍关爱,孔祥鸣.经皮穴位电刺激在阿片类药物导致的便秘管理中的疗效评价[J].浙江中西医结合杂志,2018,28(10): |
| 经皮穴位电刺激在阿片类药物导致的便秘管理中的疗效评价 |
| Evaluation of efficacy of transcutaneous electrical acupoint stimulation in the management of opioid-induced constipation |
| 投稿时间：2017-12-28 修订日期：2018-10-10 |
| DOI： |
| 中文关键词: 便秘 经皮穴位电刺激 阿片 肠功能指数 |
| 英文关键词:Constipation Transcutaneous Electrical Acupoint Stimulation Opioid Bowel Fuction Index |
| 基金项目:浙江省中医药科技计划项目，项目编号2016ZB027；浙江省医药卫生科技项目，项目编号2015KYB066,2018KY312 |
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| 中文摘要: |
| 目的：观察经皮穴位电刺激在阿片类药物所致便秘管理中的疗效。方法：选择确诊为阿片药物导致便秘的患者共146例随机分为2组，TEAS组以及对照组。所有入组患者均口服苁蓉通便口服液10ml，2次/日，TEAS组加经皮穴位电刺激治疗相关穴位，并根据症状虚实加减穴位，共治疗2周。治疗前以及治疗2周后分别记录所有患者肠功能指数、便秘症状积分,评价便秘疗效,生活质量评价采用便秘患者生存质量自评量表(PAC-QOL）。结果：两组在治疗后便秘均有改善。TEAS组在肠功能指数排便的总满意度为62.44±17.81，较对照组改善更明显（t=-3.64,P=0.00）。生活质量评分上TEAS组4个维度积分均有改善，其中躯体不适的积分为8.52±0.71，（t=-3.69,P=0.00)、心理和社会不适的积分为2.03±0.32，(t=-2.95,P=0.00)、满意度积分为1.14±0.29(t=-2.38,P=0.00)，这3个项目积分改善均优于对照组（P＜0.05）。从便秘症状积分上比较，TEAS组治疗后为5.10±0.51，较对照组改善更明显（t=-3.90,P=0.02）。TEAS组总有效率为93.06%，对照组为85.07%,虽然TEAS组总有效率高，但没有出现统计学差异（χ2=2.92，P=0.13）。结论：经皮穴位电刺激可以改善阿片类药物所致便秘患者的症状及生活质量。 |
| 英文摘要: |
| Objective：To assessed whether Transcutaneous Electrical Acupoint Stimulation(TEAS) is efficacious in treating patient with opioid-induced constipation(OIC).
Methods:146 patients with OIC diagnosed were randomized to recieve either true or mock TEAS for a two-week period.All patients were treated with Congrong purgative oral solution by the dose of 10ml,two times a day. Before and after two weeks of the treatment, Bowel Fuction Index( BFI)and constipation symptom scores were recorded, the efficacy of constipation evaluated, the quality of life assessed by PAC-QOL.
Results: 72cases of TEAS group and 67 cases of control group completed the two-week therapy. After the therapy, comparison with control group,there was a significantly improvement in total defecation satisfaction of BFI in TEAS group(62.44±17.81,t=-3.64,P=0.00).Four dimensions scores of PAC-QOL of TEAS group were improved in varying degrees.The scores were 8.52±0.71（t=-3.69,P=0.00）in physical discomfort dimension, 2.03±0.32,（t=-2.95,P=0.00）in psychological and social discomfort dimension,and 1.14±0.29（t=-2.38,P=0.00）in satisfaction dimension,respectively.The scores of the above three dimensions improved significantly than that of the control group (p﹤0.05 ). Constipation symptom scores of the TEAS group was5.10±0.51 ,improved significantly compared with the control group(t=-3.90,P=0.02). The total effective rate were 93.06% in TEAS group, and 85.07% in the control group.However there was no significant difference between the two groups（χ2=2.92，P=0.13）.
Conclusion:Transcutaneous electrical stimulation at acupoints is capable of improving symptoms and quality of life in patients with opioid-induced constipation. |
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