| 梅仕锋.无抽搐电休克对精神分裂症患者认知功能及短时记忆损伤的影响[J].浙江中西医结合杂志,2019,29(3): |
| 无抽搐电休克对精神分裂症患者认知功能及短时记忆损伤的影响 |
| The influence on short-term memory impairment and cognitive function of non-convulsive electroconvulsive treatment for schizophreniaMei Shifeng, Yiwu mental health center, psychiatry 322000 |
| 投稿时间：2018-07-04 修订日期：2018-08-05 |
| DOI： |
| 中文关键词: 精神分裂症 无抽搐电休克 记忆损伤 认知功能 临床疗效 |
| 英文关键词: |
| 基金项目: |
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| 摘要点击次数: 1096 |
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| 中文摘要: |
| 目的 应用无抽搐电休克(MECT)治疗精神分裂症(SP)患者,观察对患者症状的改善作用,并评估对短时记忆损伤及认知功能的影响,为SP的临床治疗提供依据。方法 选择本院2016年1月～2017年7月SP患者90例,根据入院编号按照单双号随机分为对照组和研究组,两组各45例,对照组患者进行常规治疗,研究组在对照组治疗基础上进行无抽搐电休克治疗。分别于治疗前、治疗3周和6周后应用阳性和阴性症状量表(PANSS)、连线试验 A(TMT-A)和 B(TMT-B)评估患者症状和认知功能的改善状况,采用韦氏记忆量表(WMS) 以记忆商数(MQ)评估患者短时记忆功能状况。结果 研究组患者治疗3周和6周PANSS阳性症状、阴性症状、总评分和TMT-A和TMT-B分别为(11.51±0.94)分、(11.41±0.65)分、(39.23±2.30)分、(8.39±0.97)分、(8.92±0.69)分、(31.46±2.17)分、(62.43±3.04)s、(95.31±4.86)s、(54.26±2.85)s、(89.46±4.72)s,均低于对照组(13.27±1.06)分、(12.49±0.78)分、(42.72±2.26)分、(9.98±0.91)分、(10.05±0.72)分、(35.24±2.55)分、(65.62±3.21)s、(98.69±5.04)s、(57.39±2.86)s、(91.44±5.12)s,差异有统计学意义(P＜0.05)。研究组患者治疗3周和6周后MQ结果为(69.23±2.30)分和(70.46±2.17)分,均低于治疗前,但治疗6周后高于治疗3周后,差异有统计学意义(P＜0.05)。结论 应用MECT治疗SP患者,能够有效改善患者的精神症状、认知功能,对患者短时记忆有一定损伤,但可较快得到恢复。 |
| 英文摘要: |
| Objective Patients with schizophrenia (SP) treated with non-convulsive electroconvulsive shock(MECT),to observe its clinical curative effect and evaluate the impact on short-term memory impairment and cognitive function, and provide basis for clinical treatment of SP patients. Methods 90 SP patients in hospital were selected from January in 2016 to July in 2017,they were divided into the control group and study group according to the admission single and double numbers randomly,45 patients in each group.The control group received routine treatment,and the study group was performed electroconvulsive therapy without convulsions on the basis of control group. The positive and negative symptom scores (PANSS), connection test A (TMT-A) and B (TMT-B) were used to assess the improvement of symptoms and cognitive function before treatment, 3 weeks and 6 weeks after treatment. Wechsler Memory Scale (WMS) was used to evaluate the short-term memory function of patients with memory quotient (MQ) Results PANSS positive symptoms, negative symptoms, total scores and TMT-A and TMT-B of study group after treatment 3 and 6 weeks were (11.51±0.94) points, (11.41±0.65) points, (39.23±2.30) points, 8.39±0.97) points, (8.92±0.69) points, (31.46±2.17) points, (62.43±3.04)s, (95.31±4.86)s, (54.26±2.85)s, (89.46±4.72)s respectively, all lower than the control group (13.27±1.06) points, (12.49±0.78) points, (42.72±2.26) points, (9.98±0.91) points, (10.05±0.72) points, (35.24±2.55) points, (65.62±3.21)s, (98.69 ± 5.04) s, (57.39 ± 2.86) s, (91.44 ± 5.12) s, the difference was statistically significant (P <0.05). After treatment for 3 weeks and 6 weeks,MQ results of the study group were (69.23±2.30) points and (70.46±2.17) points, which were all lower than before treatment, however MQ results after treatment six weeks higher than after treatment three weeks,the difference was statistically significant(P<0.05).Conclusion Application MECT for the treatment of patients with SP can effectively improve the patient"s psychiatric symptoms, cognitive function. The patient"s short-term memory has some damage, while it can be restored quickly. |
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