| 陈春,邵思思,刘张红.补中益气汤对慢性肾炎患者全身微炎症状态及TLRs/MYD88信号通路的影响[J].浙江中西医结合杂志,2019,29(9): |
| 补中益气汤对慢性肾炎患者全身微炎症状态及TLRs/MYD88信号通路的影响 |
| Effect of Buzhong Yiqi Decoction on Systemic Microinflammation and TLRs/MYD88 Signaling Pathway in Patients with Chronic Nephritis |
| 投稿时间：2018-12-20 修订日期：2019-08-09 |
| DOI： |
| 中文关键词: 补中益气汤 慢性肾炎 炎症因子 TLRs/MYD88 |
| 英文关键词:Buzhong Yiqi Decoction Chronic Nephritis Inflammatory Factor TLRs/MYD88 |
| 基金项目:温州市科技局项目Y20170324 |
|
| 摘要点击次数: 930 |
| 全文下载次数: 0 |
| 中文摘要: |
| 目的：探讨补中益气汤对慢性肾炎患者全身微炎症状态及TLRs/MYD88信号通路的影响。 方法：将慢性肾炎患者80例随机分为2组，各40例。
对照组给予氯沙坦钾片 100mg qd 口服。观察组在对照组治疗基础上加用补中益气汤治疗。两组疗程均为8周。采用比色法测24h尿蛋白定量（24h Upro）；采用酶联免疫吸附法（ELISA）测定血尿素氮（BUN）、肌酐（Scr）、肿瘤坏死因子-α（TNF -α）、白介素-6 （IL -6）；采用RT -PCR检测TLR2、TLR4、MYD88 mRNA。结果：经治疗后，2组患者24h Upro、BUN、Scr均较同组治疗前明显降低，而观察组较对照组降低更显著，差异有统计学意义（P <0.05）。经治疗后，2组患者TNF -α、IL -6均较同组治疗前明显降低，而观察组较对照组降低更显著，差异有统计学意义（P <0.05）。经治疗后，观察组患者TLR2、TLR4、MYD88 mRNA显著低于对照组，差异有统计学意义（P <0.05），而对照组治疗前后无明显差异（P＞0.05）。结论：补中益气汤可以改善CGN患者肾功能，抑制其微炎症状态，其机制可能与抑制抑制TLRs/MYD88信号通路相关。 |
| 英文摘要: |
| Objective: To explore the effect of Buzhong Yiqi Decoction on systemic microinflammation and TLRs/MYD88 signaling pathway in patients with chronic nephritis. Methods: 80 cases of patients with chronic nephritis were randomly divided into two groups, 40 in each group. Control group was given losartan potassium tablets 100 mg QD orally. Observation group was treated with Buzhong Yiqi Decoction on the basis of Control group. Both groups were treated for 8 weeks. 24-hour urinary protein quantification (24h Upro) was determined by colorimetry, blood urea nitrogen (BUN), creatinine (Scr), tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6) by enzyme-linked immunosorbent assay (ELISA),and TLR2, TLR4 and MYD88 were detected by RT-PCR. Results: After treatment, the 24h Upro, BUN and Scr of the two groups were significantly lower than those of the same group before treatment, while Observation group was significantly lower than Control group (P < 0.05). After treatment, the levels of TNF-a and IL-6 in the two groups were significantly lower than those in the same group before treatment, while those in Observation group were significantly lower than those in Control group (P < 0.05). After treatment, the TLR2, TLR4 and MYD88 in Observation group were significantly lower than those in Control group (P < 0.05), but there was no significant difference before and after treatment in the control group (P > 0.05). Conclusion: Buzhong Yiqi Decoction can improve renal function and inhibit microinflammation in CGN patients. Its mechanism may be related to inhibiting TLRs/MYD88 signaling pathway. |
| 查看全文 查看/发表评论 下载PDF阅读器 |
| 关闭 |
